A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions

Gyan Hari Aryal; Cooper Hawkins Battle; Tod A. Grusenmeyer; Mengyuan Zhu; Janarthanan Jayawickramarajah

doi:10.1039/C5CC08350H

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A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions†

Gyan Hari Aryal,‡^a Cooper Hawkins Battle,‡^a Tod A. Grusenmeyer,^a Mengyuan Zhu^a and Janarthanan Jayawickramarajah*^a

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* Corresponding authors

^a Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana, USA
E-mail: jananj@tulane.edu

Abstract

A naphthalimide based fluorescent sensor displaying a significant increase in emission upon binding CB[7] with notable pH stability was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes. Previously unknown binders with moderate to strong affinities were discovered.

This article is part of the themed collections: Suprabiomolecular Chemistry and Host–guest chemistry

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Article information

DOI: https://doi.org/10.1039/C5CC08350H
Article type: Communication
Submitted: 07 Oct 2015
Accepted: 16 Dec 2015
First published: 16 Dec 2015

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Chem. Commun., 2016,52, 2307-2310

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A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions

G. H. Aryal, C. H. Battle, T. A. Grusenmeyer, M. Zhu and J. Jayawickramarajah, Chem. Commun., 2016, 52, 2307 DOI: 10.1039/C5CC08350H

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Chemical Communications

A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions†

Abstract

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A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions

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