Introduction to biomimetic therapeutics
Yongzhuo Huang and Jianqing Gao introduce the Biomaterials Science themed issue on biomimetic therapeutics.
Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics
Protein cages found in nature have evolved for a variety of purposes and this review focuses on how they are being co-opted for use in immunotherapy and therapeutic delivery.
Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering
Biomimetic hydrogels work as tissue engineering scaffolds by recapitulating chemical cues and mimicking spatiotemporal characteristics of the native extracellular matrix.
Advances in living cell-based anticancer therapeutics
This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.
Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells
The design strategies of particle adjuvants by mimicking natural pathogens to strengthen their interaction with antigen-presenting cells.
Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria
Antibiotic drugs have revolutionized the field of medicine for almost 90 years. However, continued use has led to the rise of antibiotic resistant bacteria. To combat these bacteria, biomimetic material strategies have been investigated.
Biomimetic drug-delivery systems for the management of brain diseases
This review summarizes the biological properties of biomimetic DDSs and their applications in the treatment of CNS diseases.
Virus-derived materials: bury the hatchet with old foes
Viruses, with special architecture and unique biological nature, can be utilized for various biomedical applications.
Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy
Supramolecular peptide assemblies can mimic natural viruses and serve as well-defined, dynamic and multifunctional nanoplatforms for cancer immunotherapy, where the peptide segments act as antigens, adjuvants and carriers.
Biomimetic and bioinspired strategies for oral drug delivery
Herein we provide a state-of-the-art review on the current progress of biomimetic particulate oral delivery systems.
Biomimetic cell-derived nanocarriers for modulating immune responses
In this review, we summarize various applications of biomimetic carriers in modulating immune responses and discuss the future perspectives.
Self-assembling peptide-based nanodrug delivery systems
The present review outlines the methods designing self-assembling peptide-based NDDs for small molecule drugs, with an emphasis on the different drug delivery strategies and their applications in using peptides and peptide conjugates.
Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma
We engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment.
Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy
For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA.
A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery
A new insulin analog has been obtained by modifying insulin with forskolin (designated as insulin-F), a glucose transporter (Glut) inhibitor. Insulin-F is capable of binding to Glut on the plasma membrane in a glucose-dependent manner.
Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles
While highly promising in medicine, gene therapy requires delivery agents to protect and target nucleic acid therapeutics.
Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria
Combining nanozymes and bacteria to eliminate dental biofilms in a mixed-species model.
Cytosine-functionalized bioinspired hydrogels for ocular delivery of antioxidant transferulic acid
Cytosine endows HEMA hydrogels with affinity for antioxidants, such as transferulic acid (TA), having complementary hydrogen bonding and π–π stacking ability. The affinity was reinforced with EGPEM, suggesting molecular cleft-like binding sites.
Biomimetic polymeric nanoparticle-based photodynamic immunotherapy and protection against tumor rechallenge
In this study, we sought to design a bionanomaterial that could exert anticancer effects against primary tumors and protect against rechallenged tumors via photodynamic immunotherapy.
A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis
A cell-based biomimetic delivery system characterized by its “Trojan horse” property is developed, in which the PDA-Ce6 nanoparticles were loaded in the MSCs for tumor-targeted delivery and combination PDT/PTT for retarding lung melanoma metastasis.
Engineering microglia as intraoperative optical imaging agent vehicles potentially for fluorescence-guided surgery in gliomas
Carotid artery injection of DiDBV2-Fe into glioblastoma-bearing mice and rats potentially for fluorescence-guided tumor surgery leads to significant accumulation and retention by the brain tumors.
Tannic acid-based nanogel as an efficient anti-inflammatory agent
Biologically produced reactive oxygen species (ROS) are important signaling molecules in the human body.
Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers
Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they have restricted therapeutic potential.
Biomimetic proteoglycan nanoparticles for growth factor immobilization and delivery
Growth factor delivery is often challenging due to their short half-life, low stability, and rapid deactivation. Here, we engineered novel biomimetic proteoglycan nanocarriers for the immobilization and controlled release of growth factors.
About this collection
This collection on Biomimetic Therapeutics (BTs) presents the latest advances in biomimetic delivery and therapy, and offer an overview of various cutting-edge theranostics strategies. The collection has been Guest Edited by Professor Yongzhuo Huang (Shanghai Institute of Materia Medica, CAS) and Professor Jianqing Gao (Zhejiang University) and it will include research on topics such as endogenous elements, cell-membrane camouflaged BTs, cell-based BTs, and bacteria or virus-mimicking BTs.