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Themed collection Biomimetic Therapeutics

24 items
Editorial

Introduction to biomimetic therapeutics

Yongzhuo Huang and Jianqing Gao introduce the Biomaterials Science themed issue on biomimetic therapeutics.

Graphical abstract: Introduction to biomimetic therapeutics
From the themed collection: Biomimetic Therapeutics
Minireview

Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics

Protein cages found in nature have evolved for a variety of purposes and this review focuses on how they are being co-opted for use in immunotherapy and therapeutic delivery.

Graphical abstract: Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics
From the themed collection: Biomimetic Therapeutics
Review Article

Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering

Biomimetic hydrogels work as tissue engineering scaffolds by recapitulating chemical cues and mimicking spatiotemporal characteristics of the native extracellular matrix.

Graphical abstract: Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering
From the themed collection: Biomimetic Therapeutics
Review Article

Advances in living cell-based anticancer therapeutics

This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.

Graphical abstract: Advances in living cell-based anticancer therapeutics
From the themed collection: Biomimetic Therapeutics
Review Article

Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells

The design strategies of particle adjuvants by mimicking natural pathogens to strengthen their interaction with antigen-presenting cells.

Graphical abstract: Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells
From the themed collection: Biomimetic Therapeutics
Review Article

Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria

Antibiotic drugs have revolutionized the field of medicine for almost 90 years. However, continued use has led to the rise of antibiotic resistant bacteria. To combat these bacteria, biomimetic material strategies have been investigated.

Graphical abstract: Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria
From the themed collection: Biomimetic Therapeutics
Review Article

Biomimetic drug-delivery systems for the management of brain diseases

This review summarizes the biological properties of biomimetic DDSs and their applications in the treatment of CNS diseases.

Graphical abstract: Biomimetic drug-delivery systems for the management of brain diseases
From the themed collection: Biomimetic Therapeutics
Review Article

Virus-derived materials: bury the hatchet with old foes

Viruses, with special architecture and unique biological nature, can be utilized for various biomedical applications.

Graphical abstract: Virus-derived materials: bury the hatchet with old foes
From the themed collection: Biomimetic Therapeutics
Review Article

Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy

Supramolecular peptide assemblies can mimic natural viruses and serve as well-defined, dynamic and multifunctional nanoplatforms for cancer immunotherapy, where the peptide segments act as antigens, adjuvants and carriers.

Graphical abstract: Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy
From the themed collection: Biomimetic Therapeutics
Review Article

Biomimetic and bioinspired strategies for oral drug delivery

Herein we provide a state-of-the-art review on the current progress of biomimetic particulate oral delivery systems.

Graphical abstract: Biomimetic and bioinspired strategies for oral drug delivery
From the themed collection: Biomimetic Therapeutics
Review Article

Biomimetic cell-derived nanocarriers for modulating immune responses

In this review, we summarize various applications of biomimetic carriers in modulating immune responses and discuss the future perspectives.

Graphical abstract: Biomimetic cell-derived nanocarriers for modulating immune responses
From the themed collection: Biomimetic Therapeutics
Review Article

Self-assembling peptide-based nanodrug delivery systems

The present review outlines the methods designing self-assembling peptide-based NDDs for small molecule drugs, with an emphasis on the different drug delivery strategies and their applications in using peptides and peptide conjugates.

Graphical abstract: Self-assembling peptide-based nanodrug delivery systems
From the themed collection: Biomimetic Therapeutics
Communication

Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma

We engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment.

Graphical abstract: Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma
From the themed collection: Biomimetic Therapeutics
Communication

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA.

Graphical abstract: Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy
From the themed collection: Biomimetic Therapeutics
Communication

A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery

A new insulin analog has been obtained by modifying insulin with forskolin (designated as insulin-F), a glucose transporter (Glut) inhibitor. Insulin-F is capable of binding to Glut on the plasma membrane in a glucose-dependent manner.

Graphical abstract: A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery
From the themed collection: Biomimetic Therapeutics
Communication

Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles

While highly promising in medicine, gene therapy requires delivery agents to protect and target nucleic acid therapeutics.

Graphical abstract: Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles
From the themed collection: Biomimetic Therapeutics
Paper

Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria

Combining nanozymes and bacteria to eliminate dental biofilms in a mixed-species model.

Graphical abstract: Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria
From the themed collection: Biomimetic Therapeutics
Paper

Cytosine-functionalized bioinspired hydrogels for ocular delivery of antioxidant transferulic acid

Cytosine endows HEMA hydrogels with affinity for antioxidants, such as transferulic acid (TA), having complementary hydrogen bonding and π–π stacking ability. The affinity was reinforced with EGPEM, suggesting molecular cleft-like binding sites.

Graphical abstract: Cytosine-functionalized bioinspired hydrogels for ocular delivery of antioxidant transferulic acid
From the themed collection: Biomimetic Therapeutics
Paper

Biomimetic polymeric nanoparticle-based photodynamic immunotherapy and protection against tumor rechallenge

In this study, we sought to design a bionanomaterial that could exert anticancer effects against primary tumors and protect against rechallenged tumors via photodynamic immunotherapy.

Graphical abstract: Biomimetic polymeric nanoparticle-based photodynamic immunotherapy and protection against tumor rechallenge
From the themed collection: Biomimetic Therapeutics
Paper

A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis

A cell-based biomimetic delivery system characterized by its “Trojan horse” property is developed, in which the PDA-Ce6 nanoparticles were loaded in the MSCs for tumor-targeted delivery and combination PDT/PTT for retarding lung melanoma metastasis.

Graphical abstract: A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis
From the themed collection: Biomimetic Therapeutics
Paper

Engineering microglia as intraoperative optical imaging agent vehicles potentially for fluorescence-guided surgery in gliomas

Carotid artery injection of DiDBV2-Fe into glioblastoma-bearing mice and rats potentially for fluorescence-guided tumor surgery leads to significant accumulation and retention by the brain tumors.

Graphical abstract: Engineering microglia as intraoperative optical imaging agent vehicles potentially for fluorescence-guided surgery in gliomas
From the themed collection: Biomimetic Therapeutics
Paper

Tannic acid-based nanogel as an efficient anti-inflammatory agent

Biologically produced reactive oxygen species (ROS) are important signaling molecules in the human body.

Graphical abstract: Tannic acid-based nanogel as an efficient anti-inflammatory agent
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers

Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they have restricted therapeutic potential.

Graphical abstract: Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Biomimetic proteoglycan nanoparticles for growth factor immobilization and delivery

Growth factor delivery is often challenging due to their short half-life, low stability, and rapid deactivation. Here, we engineered novel biomimetic proteoglycan nanocarriers for the immobilization and controlled release of growth factors.

Graphical abstract: Biomimetic proteoglycan nanoparticles for growth factor immobilization and delivery
From the themed collection: Biomaterials Science Lectureship Winners
24 items

About this collection

This collection on Biomimetic Therapeutics (BTs) presents the latest advances in biomimetic delivery and therapy, and offer an overview of various cutting-edge theranostics strategies. The collection has been Guest Edited by Professor Yongzhuo Huang (Shanghai Institute of Materia Medica, CAS) and Professor Jianqing Gao (Zhejiang University) and it will include research on topics such as endogenous elements, cell-membrane camouflaged BTs, cell-based BTs, and bacteria or virus-mimicking BTs.

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