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Issue 4, 2020

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Author affiliations

Abstract

For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

Graphical abstract: Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Supplementary files

Article information


Submitted
27 Sep 2019
Accepted
19 Nov 2019
First published
20 Nov 2019

Biomater. Sci., 2020,8, 1101-1105
Article type
Communication

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

K. Lee, S. Y. Kim, Y. Seo, M. H. Kim, J. Chang and H. Lee, Biomater. Sci., 2020, 8, 1101 DOI: 10.1039/C9BM01564G

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