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Issue 8, 2019

Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles

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Abstract

While highly promising in medicine, gene therapy requires delivery agents to protect and target nucleic acid therapeutics. We developed a plant viral siRNA delivery platform making use of self-assembling cowpea chlorotic mottle virus (CCMV). CCMV was loaded with siRNAs targeting GFP or FOXA1; to further enhance cell uptake and intracellular trafficking, resulting in more efficient gene knockdown, we appended CCMV with a cell penetrating peptide (CPP), specifically M-lycotoxin peptide L17E.

Graphical abstract: Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles

Supplementary files

Article information


Submitted
20 May 2019
Accepted
23 Jun 2019
First published
01 Jul 2019

Biomater. Sci., 2019,7, 3138-3142
Article type
Communication

Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles

P. Lam and N. F. Steinmetz, Biomater. Sci., 2019, 7, 3138 DOI: 10.1039/C9BM00785G

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