Themed collection Biomaterials Science Recent HOT Articles
Nanoscale metal–organic frameworks for the intracellular delivery of CRISPR/Cas9 genome editing machinery
The discovery of CRISPR/Cas9 genome-editing technology enables the precise manipulation of mammalian DNA sequences for treating genetic disorders.
Application and research progress of phase change materials in biomedical field
Application of phase change materials (PCMs) in biomedical field.
In situ self-assembled peptide nanofibers for cancer theranostics
Nanofibers constructed by an in situ self-assembly strategy hold tremendous promise for cancer theranostics with characteristic functions and biological effects in different parts of tumor tissue.
Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity
Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging.
Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation
Nanomedicine recognition and clearance by the mononuclear phagocyte system (MPS) impedes optimal clinical impacts for this class of materials. We present an overview of factors involved in MPS interactions and approaches to overcome this barrier.
Engineering of protein crystals for use as solid biomaterials
Protein crystal engineering both in vitro and within cells has led to advances in protein crystallization and generation of solid functional materials.
Recent developments in mussel-inspired materials for biomedical applications
Over the decades, researchers have strived to synthesize and modify nature-inspired biomaterials, with the primary aim to address the challenges of designing functional biomaterials for regenerative medicine and tissue engineering.
Deoxyribonucleic acid anchored on cell membranes for biomedical application
This review provides an overview of engineering cellular membranes with deoxyribonucleic acids to manipulate cellular behaviors and functionalities for biomedical applications. The current challenges and future directions are summarized and proposed.
Marine origin materials on biomaterials and advanced therapies to cartilage tissue engineering and regenerative medicine
This comprehensive review brings a larger perspective on the most recent developments in new tissue-scaffolds based on marine origin polymers envisaging the treatment and repair of human articular cartilage tissues.
Recent progress in nanotechnology-based drug carriers for celastrol delivery
Various types of celastrol nanoformulations have been developed to treat a number of disorders, including cancer, inflammatory, auto-immune, obesity.
DNA-coated gold nanoparticles for tracking hepatocyte growth factor secreted by transplanted mesenchymal stem cells in pulmonary fibrosis therapy
Based on the fluorescence off–on principle, a dye-labeled Au nanoflare tracer is presented for in vivo tracking the secretion of hepatocyte growth factor (HGF) by MSCs during idiopathic pulmonary fibrosis (IPF) therapy.
Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22
Interleukin (IL)-22 is a multifunctional cytokine with a very short half-life that activates STAT3 and can elicit an anti-inflammatory response. We show encapsulation of IL-22 in LPMSN enhances its biological activity and stability in in vitro and human colonic organoids.
Non-contact measurement of internal body temperature using subcutaneously implanted diamond microparticles
We demonstrate the feasibility of subcutaneously implanted fluorescent diamond microparticles as a temperature probe for the non-contact measurement of internal body temperature using a homemade wide-field optically detected magnetic resonance imager.
In situ forming injectable γ-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control
An injectable adhesive hydrogel based on N-hydroxysuccinimide γ-poly(glutamic acid) and 4-armed poly(ethylene glycol) amine showed rapid gelation time, strong mechanical strength, satisfactory burst pressure and excellent hemostatic performance.
Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases
Flash nanotechnology-produced nanomedicines exhibit potent antioxidant and anti-inflammatory properties and could overcome mucosal barrier for oral delivery, resulting in great efficiency in the prevention and treatment of colitis-associated colorectal cancer.
A component-optimized chemo-dynamic nanoagent for enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model
A component-optimized chemo-dynamic nanoagent achieved an enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model.
Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture
Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.
Functionalized boron nanosheets with near-infrared-triggered photothermal and nitric oxide release activities for efficient antibacterial treatment and wound healing promotion
A multifunctional nanoplatform has been developed based on boron nanosheets loaded quaternized chitosan and NO donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine for rapid, and effective treatment of pathogenic bacteria.
Plant-inspired Pluronic–gallol micelles with low critical micelle concentration, high colloidal stability, and protein affinity
Plant-inspired gallol-containing surfactants have been successfully incorporated into typical Pluronic® micelles, allowing low critical micelle concentration, great colloidal stability, and exterior enzyme resistance.
Enhanced human T cell expansion with inverse opal hydrogels
Lymph node-inspired 3D hydrogels with precisely defined porosity were produced, which improve the state-of-the-art T cell proliferation, a procedure that is especially important for novel cellular immunotherapies.
The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid
The polymer dual drug conjugate synthesized by coupling docetaxel (DTX) and docosahexaenoic acid (DHA) with bifunctionalized dextran is selectively accumulated in tumor and nearly eradicates all MCF-7 tumors bearing in nude mice.
Fatty acid-based polymeric micelles to ameliorate amyloidogenic disorders
Fatty acid-tethered polymers were synthesized via RAFT method to explore their potential role in preventing insulin aggregation process. The results endowed fatty acid-tethered polymers with properties to act as novel anti-amyloidogenic agents.
Tailored therapeutic release from polycaprolactone-silica hybrids for the treatment of osteomyelitis: antibiotic rifampicin and osteogenic silicates
Polycaprolactone/silica hybrids offer a dual therapeutic effect: the promotion of bone regeneration thanks to silicate ions and strong antibacterial properties against the risk of osteomyelitis.
Near-infrared aggregation-induced emission nanodots for early diagnosis of tongue squamous cell carcinoma and sentinel lymph node mapping
By developing DPA-TPE-DCM with intense near-infrared fluorescence emission in the aggregation state, AIE materials were used for the first time in the early diagnosis of orthotopic TSCC and SLN mapping in an orthotopic TSCC-bearing mouse model.
Development of anticancer peptides with low hemolysis, high penetrating membrane activity, certain analgesic activity and the synergistic anticancer effect
Amphiphilic cationic anticancer lipopeptide P10 self-assembles into spherical aggregates, which are used as drug carriers to play a synergistic anticancer role, and its anticancer mechanism is presented.
Bionic biphasic composite scaffolds with osteochondrogenic factors for regeneration of full-thickness osteochondral defects
A bionic biphasic composite scaffold with on-demand osteochondrogenic factors facilitated the regeneration of osteochondral defects.
Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis
The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.
Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization
In this work, capillary tubes with different diameters were chosen to mimic a confined environment and the effect of space on the self-assembly behavior of short peptides with different oil-water partition coefficients (log P) was investigated.
A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin
We have designed a dual-function microneedle patch that integrates treatment and diagnosis.
Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.
Medical gloves modified by a one-minute spraying process with blood-repellent, antibacterial and wound-healing abilities
A kind of blood-repellent mist spray (MS) was proposed to prevent blood adhesion during surgery and played an important role in antibacterial and wound-healing, which could be widely used in the surface modification of various medical gloves.
Enhancement of intercellular interaction between iPSC-derived neural progenitor cells and activated endothelial cells using cell surface modification with functional oligopeptides
Stroke activated Endothelial Cells recruit leucocytes for further necrosis. Esbp-PEG-lipid modified cells can bind to these ECs for a rather protective effect and reduced leucocyte binding.
Facile discovery of a therapeutic agent for NK-mediated synergistic antitumor effects using a patient-derived 3D platform
3D tumor spheroid/NK co-culture platform facilitates the discovery of a small drug, C19, for synergistic NK-mediated cytolysis against pancreatic cancer patient-derived cancer spheroid.
Nanodot-doped peptide hydrogels for antibacterial phototherapy and wound healing
Antimicrobial peptide hydrogels combined with phototherapy in the treatment of infected wounds.
Planar organization of airway epithelial cell morphology using hydrogel grooves during ciliogenesis fails to induce ciliary alignment
Here we align airway epithelial cells on hydrogel grooves and induce apical-basal polarization and cilia formation. Neither initial alignment, nor maintained alignment on the grooves induced polarized cilia alignment in the epithelial sheet.
Isolation and characterization of porcine macrophages and their inflammatory and fusion responses in different stiffness environments
Evaluating the host immune response to biomaterials is an essential step in the development of medical devices and tissue engineering strategies.
A tripartite carbohydrate-binding module to functionalize cellulose nanocrystals
mSA-CBM3-AzF is a chimeric protein targeting cellulose nanocrystals (CNCs) with high affinity. It presents two additional domains providing a wide choice of chemical and biological molecules to functionalize CNCs.
Improved epithelial cell–cell adhesion using molecular mobility of supramolecular surfaces
The role of molecular mobility on polyrotaxane surfaces was investigated in epithelial cell–cell adhesion. The polyrotaxane surfaces with higher mobility induced cytoplasmic YAP localization, leading to stronger cell–cell adhesion.
The in vivo fate of tobacco mosaic virus nanoparticle theranostic agents modified by the addition of a polydopamine coat
The coating of tobacco mosaic virus (TMV) nanoparticles Gd-Cy5-TMV with polydopamine (PDA) increased protein corona formation and shortened plasma circulation, but minimized recognition by anti-TMV antibodies, and extended organ distribution/clearance.
A multifunctional green antibacterial rapid hemostasis composite wound dressing for wound healing
A green multifunctional wound dressing with low-cost that can accelerate wound healing in comparison to gauze.
Dual-sensitive dual-prodrug nanoparticles with light-controlled endo/lysosomal escape for synergistic photoactivated chemotherapy
The dual-sensitive dual-prodrug nanoparticles (DDNPs) with light-controlled drug-release on demand and endo/lysosomal escape for synergistic photoactivated chemotherapy.
Interrogating cardiac muscle cell mechanobiology on stiffness gradient hydrogels
Mechanobiology of H9C2 cells and neonatal cardiomyocytes mapped using stiffness gradient hydrogels with a range of extracellular matrix coatings, revealing stiffness-driven trends in cell morphology, YAP and MRTF-A expression.
A facile method for high-throughput screening of drug-eluting coatings in droplet microarrays based on ultrasonic spray deposition
Droplet microarrays are fabricated for the high-throughput screening of drug-eluting coatings via ultrasonic spray deposition technique.
Microneedle-mediated delivery of MIL-100(Fe) as a tumor microenvironment-responsive biodegradable nanoplatform for O2-evolving chemophototherapy
MIL-100(Fe) nanoparticles integrated microneedles were employed to codeliver the hydrophobic photosensitizer zinc phthalocyanine (ZnPc) and the chemotherapeutical drug doxorubicin hydrochlorate (Dox) (Z/D@MOF) for O2-evolving chemophototherapy.
c-Met-targeted near-infrared fluorescent probe for real-time depiction and dissection of perineural invasion and lymph node metastasis lesions in pancreatic ductal adenocarcinoma xenograft models
c-Met-targeted near-infrared fluorescent probe has excellent targeting ability to pancreatic ductal adenocarcinoma (PDAC), and can be used for real-time detection of lymph node metastasis and perineural invasion lesions in PDAC xenograft models.
Pre-shear bioprinting of highly oriented porous hydrogel microfibers to construct anisotropic tissues
A pre-shear bioprinting strategy of oriented porous cell-laden hydrogel microfiber to construct anisotropic tissues is first proposed. Different cells encapsulated in the oriented microfibers exhibit oriented growth behaviors similar to that in vivo.
Hydrophilic hindering and hydrophobic growing: a vesicle glycometabolism multi-drug combination therapeutic against Alzheimer's disease
Advanced drug vehicle exploitation and the sophisticated synergy mechanism revelation are two great difficulties in combination therapy.
A sulfonate-based polypeptide toward infection-resistant coatings
We developed a mono-component and sulfonate-based polypeptide coating with reversible on-demand bactericidal and antifouling properties.
High-stability NIR-II fluorescence polymer synthesized by atom transfer radical polymerization for application in high-resolution NIR-II imaging
This article reports a high-stability NIR-II fluorescence polymer synthesized by atom transfer radical polymerization for application in high-resolution NIR-II imaging.
Plasmonic enhanced enzyme activity by catalytic cascade induced mutual benefit tumor starvation/immune/photothermal therapy
Single tumor starvation therapy can activate other signaling pathways in tumor cells and easily induce tumor cell metastasis.
Dual-sonosensitizer loaded phase-transition nanoparticles with tumor-targeting for synergistically enhanced sonodynamic therapy
Sonodynamic therapy (SDT) is a fast-growing therapy activated by using ultrasound to initiate a catalytic reaction of sensitizing agents and kill tumor cells through producing reactive oxygen species (ROS).
Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors
An illustration of black phosphorus (BP) assisted polyionic mPEG-PDMATC micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors.
Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy
A reliable approach is developed to formulate a targeted lipid-coated nanomedicine based on UCNP and co-loaded with CO-prodrug and vitamin E, which can convert NIR light to UV photon to release CO for synergistical cancer therapy with vitamin E.
A pH-triggered fluorescence-switchable extracellular vesicle for tracing drug release and improving drug delivery
A pH-triggered fluorescence-switchable extracellular vesicle is developed by loading zwitterionic fluorescent carbon dots into macrophage cell-secreted vesicles, which enables to improve drug delivery and monitor drug release in real time.
Synthesis of a zwitterionic N-Ser–Ser-C dimethacrylate cross-linker and evaluation in polyampholyte hydrogels
Polyampholyte hydrogels are attractive materials for tissue engineering scaffolds as they offer a wide variety of features including nonfouling, selective protein delivery, and tunable physical characteristics.
About this collection
Welcome to our online rolling collection of the hottest work published in Biomaterials Science. Here we feature recent Biomaterials Science articles highlighted as HOT by the handling editor or our referees.
Congratulations to all the authors whose articles are featured.