Themed collection Biomaterials Science Recent HOT Articles

PBA and PBE derived materials have played a crucial role in advanced healthcare technologies such as diagnostics, therapeutics and theranostics that can be useful for personalized therapies based on biomarkers of diseases.

Catechol direct modification enables the preparation of functional coatings by imparting adhesive capability to the target molecule. The catechol precursor choice affects synthetic route and substrate compatibility, allowing for tailored strategies.

Traumatic brain injury (TBI) disrupts neural pathways, leading to sensory, motor, and autonomic dysfunctions, with no fully restorative therapies currently available.

This review revisits key properties of the extracellular matrix to be replicated in hydrogels for 3D cell culture and summarizes the interplay between hydrogel structural and mechanical properties, as well as their combined impact on cell function.

Lipid adjuvants act as a fundamental element in mRNA vaccine technology by performing as diverse functional parts: augmenting immune responses, assisting genetic payload delivery to target cells, and optimizing antigen presentation.

Extracellular matrix mimicking bilayer wound dressings, combining hydrogels and electrospun nanofibers, offer a biomimetic approach for moisture retention, antibacterial activity, and pro-healing features for enhanced skin regeneration.

This review presents a multifaceted overview of how the biomanufacturing context including culture vessels, media, engineered surfaces, and workflows impact monocyte-derived dendritic cells for clinical applications.

A A 3D printed microfluidic platform for the on-demand synthesis of CaP biomaterials.

Bone is a dynamic, mechanoresponsive tissue with intrinsic mechanoelectrical behavior. Schematic (created with BioRender) illustrates how mechanical stimulation applied to a conductive scaffold enhances osteogenic differentiation.

Collagen IV-targeted phase-change nanoparticles enable precise ultrasound staging of early liver fibrosis.

Schematic illustration of platelet lysate incorporation, evaluated both within in vitro fibrin gels and in vivo microfracture clots.

Freeze–thaw-induced ageing enables the generation of homogeneous RBC-EV populations with preserved bioactivity, enhancing their standardization and applicability as biomaterials in nanomedicine.

Soft tissue-mimicking hydrogel stiffness directs macrophage polarisation: soft gels (~0.25 kPa) induce anti-inflammatory responses, while stiffer ones (~4.5 kPa) trigger inflammation, underscoring macrophages’ sensitivity to subtle mechanical changes.

A new double network hydrogel made of pullulan, dextran and alginate was developed for guided tissue repair.

Ultrasound-responsive IMDQ nano-prodrug (IMDQ-N₃ NPs) enables spatiotemporal activation, enhancing the selectivity and safety of IMDQ. Combined with US, IMDQ-N₃ NPs achieved 95.7% tumor suppression in mice.

An optical clearing, light sheet microscopy and analysis pipeline was created for decellularized ECM (dECM)-based in vitro models. Our approach quantifies cell invasion in colorectal cancer liver metastasis (CRLM) models engineered with dECM.

Upon delivery to CD44(+) endometriotic cells, Au@P_AbCD44 was internalised via clathrin-mediated endocytosis. Laser exposure of cells, based on LSPR properties, increased the temperature and promoted apoptotic over necrotic cell death.

The development of synthetic glycoarchitectures for targeted bacterial adhesion represents a promising strategy in anti-adhesion therapy.

Integration of interleukin-10 to mesenchymal stem cell-derived extracellular nanovesicles effectively enhances anti-inflammatory responses in both macrophages and DCs, ultimately accelerating the skin wound healing in vivo.