Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity
Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging.
Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics
Protein cages found in nature have evolved for a variety of purposes and this review focuses on how they are being co-opted for use in immunotherapy and therapeutic delivery.
Single-atom nanozymes for biological applications
Single-atom nanozymes with high catalytic activity, selectivity, and stability have been used in the treatment of cancer, wound trauma, and brain diseases.
Biomaterials-based approaches to model embryogenesis
Biomaterials are emerging as invaluable tools to investigate key mechanisms of human development using advance in vitro models. Nanomaterials can contribute to further refine these models.
Structured micro/nano materials synthesized via electrospray: a review
Electrospray enables the preparation of versatile spherical, non-spherical, and assembled micro/nano materials.
A call for action to the biomaterial community to tackle antimicrobial resistance
The global surge of antimicrobial resistance (AMR) is a major concern for public health and proving to be a key challenge in modern disease treatment, requiring action plans at all levels.
Polydopamine free radical scavengers
This feature article summarizes the recent progress, challenges and future directions of free radical scavengers based on polydopamine, including the integrated mechanism, current regulating strategies, and kinds of biomedical applications.
Peptide-based supramolecular hydrogels for bioimaging applications
Peptide-based supramolecular hydrogels have unique merits in bioimaging applications.
Recent advances in semiconducting polymer dots as optical probes for biosensing
This review mainly summarized the recent results that used bright polymer dots (Pdots) for the detection of different analytes such as reactive oxygen species (ROS), metal ions, pH values, and a variety of biomolecules.
Hemostatic nanotechnologies for external and internal hemorrhage management
Hemostatic nanotechnologies promote the development of various hemostatic materials for external and internal hemorrhage management.
The development of phosphorescent probes for in vitro and in vivo bioimaging
This review mainly introduces the phosphorescent probes applied in vitro and in vivo bioimaging.
Recent advances in improving tumor-targeted delivery of imaging nanoprobes
This review discusses various recent strategies based on different targeting ligands to improve the tumor-specific targeting of nanoprobes toward precision imaging diagnosis.
Photothermal bactericidal surfaces: killing bacteria using light instead of biocides
Recent developments of photothermal bactericidal surfaces based on immobilized photothermal agents to kill bacteria through hyperthermia effects are reviewed.
Development of new self-assembled cationic amino liposomes for efficient gene delivery
A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.
The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)
The potential role of borophene as a radiosensitizer in PT and BNCT was investigated.
Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites
Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles which combines scaffolding and signaling. We show that local tuning of collagen organization enhances cell differentiation.
Cascaded bio-responsive delivery of eNOS gene and ZNF580 gene to collaboratively treat hindlimb ischemia via pro-angiogenesis and anti-inflammation
The cascaded, bio-responsively delivered eNOS gene and ZNF580 gene overcome transfection bottlenecks and collaboratively exert anti-ischemic function via promoting angiogenesis and alleviating inflammation.
Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy
Photodynamic and photothermal agents for efficient antimicrobial therapy.
Increased cross-linking micelle retention in the brain of Alzheimer's disease mice by elevated asparagine endopeptidase protease responsive aggregation
The asparagine endopeptidase responsive cross-linking micelle (RCM) increased the brain retention of Alzheimer's disease mice.
Ultra-small platinum nanoparticles on gold nanorods induced intracellular ROS fluctuation to drive megakaryocytic differentiation of leukemia cells
Au@Pt nanoparticles induce chronic myeloid leukemia cells to differentiate into megakaryocytes by causing intracellular ROS fluctuations with multiple enzyme-like activities.
Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes
A facile green hand grinding technique has been adopted towards the design of three nanoscale crystalline materials that serves as an excellent selective bio tracker for intracellular lysosome.
The synthesis of two-dimensional Bi2Te3@SiO2 core–shell nanosheets for fluorescence/photoacoustic/infrared (FL/PA/IR) tri-modal imaging-guided photothermal/photodynamic combination therapy
Surface activated Bi2Te3 nanosheets (NSs) conjugated with chlorin e6 (Ce6) were developed for high-performance tumor theranostics.
Overcoming therapeutic failure in osteosarcoma via Apatinib-encapsulated hydrophobic poly(ester amide) nanoparticles
A nano-Apatinib delivery system overcomes drug resistance by targeting osteosarcoma stem-like cells.
Haemoglobin-loaded metal organic framework-based nanoparticles camouflaged with a red blood cell membrane as potential oxygen delivery systems
Metal organic frameworks are used to protect hemoglobin from denaturation thus preserving its excellent oxygen-binding and releasing properties. Decorating with cell membranes minimizes protein adsorption holding potential for long circulation.
A peptide–drug hydrogel to enhance the anti-cancer activity of chlorambucil
The CRB–FFF–cyclen could transform into a hydrogel via a heating–cooling process. The resulting hydrogel could be protonated in a tumor environment, which is beneficial for cellular uptake and anti-tumor activity.
Multi-component peptide hydrogels – a systematic study incorporating biomolecules for the exploration of diverse, tuneable biomaterials
A systematic study showcasing a library of multi-component gels using the novel gelator C14-FF and various biocomponents for the development of tuneable matrices.
The development of a Glypican-3-specific binding peptide using in vivo and in vitro two-step phage display screening for the PET imaging of hepatocellular carcinoma
An in vivo and in vitro two-step phage display screening approach to identify Glypican-3 targeting peptides for the detection of hepatocellular carcinoma with low normal liver uptake.
Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in an animal model of multiple sclerosis
The change in the architecture of glatiramer acetate results in an enhanced therapeutic effect to treat experimental autoimmune encephalomyelitis.
Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation
Glioma is the most aggressive primary malignant brain tumor.
An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance
An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.
Multi pH-sensitive polymer–drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis
Multi pH-responsive polymer-drug conjugate mixed micelles were fabricated to co-deliver doxorubicin and curcumin for synergistic suppression tumor metastasis via inhibiting the invasion, migration, intravasation and extravasation of tumor cells.
Multimodal and multifunctional nanoparticles with platelet targeting ability and phase transition efficiency for the molecular imaging and thrombolysis of coronary microthrombi
In this article, we constructed PLGA-cRGD-PFH-ICG NPs through emulsification process and then the bi-modal imaging of coronary microthrombi in ischemia/reperfusion rat model and thrombolysis of clots in vitro were both successfully completed by these NPs.
Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors
PVA-Tyr hydrogel facilitated covalent incorporation can control release of pristine growth factors while retaining their native bioactivity.
Integration of antimicrobial peptides and gold nanorods for bimodal antibacterial applications
We integrate the anti-bacterial activity of BF2b antimicrobial peptide and the photothermal sterilization of gold nanorods to kill drug-resistant bacteria.
Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway
Schematic representing the anti-cancer effects of nano-HAPs both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway.
An RGD modified water-soluble fluorophore probe for in vivo NIR-II imaging of thrombosis
Synthesis of an organic near-infrared second-window fluorescent probe targeting in vivo and in vitro thrombi.
Silk degumming time controls horseradish peroxidase-catalyzed hydrogel properties
We report a fundamental study on effect of different silk degumming time on biomaterial properties of enzymatically crosslinked hydrogels.
Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons
An iron oxide nanoparticle conjugated with a cocaine analogue exhibits small size and long-term stability with the ability to target dopamine transporter-expressing neurons and provides excellent contrast enhancement under MRI, demonstrating great potential for neuroimaging.
Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury
ICAM-1 siRNA delivery mediated by bioreducible, branched BPAE-SS toward the anti-inflammatory treatment of myocardial IR injury.
Customized hydrogel substrates for serum-free expansion of functional hMSCs
Synthetic hydrogel arrays combined with a design of experiments approach identified hydrogel compositions for media-agnostic human mesenchymal stromal cell culture.
Hollow ferric-tannic acid nanocapsules with sustained O2 and ROS induction for synergistic tumor therapy
HFe-TA nanoparticles, with a fine hollow microstructure, are synthesized and incorporated with ICG for synergistic photo/chemodynamic therapy with enhanced efficacy.
Cationic copolymer enhances 8–17 DNAzyme and MNAzyme activities
Cationic copolymer acts as a chaperone to facilitate multiple strand assembly and enhance nucleic acid enzyme activities.
A novel injectable pH–temperature sensitive hydrogel containing chitosan–insulin electrosprayed nanosphere composite for an insulin delivery system in type I diabetes treatment
A novel injectable insulin hydrogel composite delivery system was prepared and characterized.
Theranostic supramolecular polymers formed by the self-assembly of a metal-chelating prodrug
The direct linkage of two camptothecin moieties to a metal chelator creates a self-assembling prodrug capable of associating in aqueous solution into theranostic supramolecular polymers.
Ultrasound monitoring of magnet-guided delivery of mesenchymal stem cells labeled with magnetic lipid–polymer hybrid nanobubbles
Mesenchymal stem cells labeled with positively charged magnetic lipid–polymer hybrid nanobubbles could be tracked for magnet-guided delivery onto the site of an injured artery using ultrasound.
A novel poly-ε-lysine based implant, Proliferate®, for promotion of CNS repair following spinal cord injury
Prolierate® is a promisingcandidate for SCI implantation.
An in vitro and in vivo comparison of Mg(OH)2-, MgF2- and HA-coated Mg in degradation and osteointegration
HA film shows favorable in vivo osteogenesis and osteointegration, while MgF2 film shows favorable in vitro osteogenic differentiation and angiogenic behavior.
Coupling PEG-LZM polymer networks with polyphenols yields suturable biohydrogels for tissue patching
A highly tough hydrogel tissue patch based on multiple non-covalent interactions between polyphenols and PEG-LZM networks has multiple biological activities.
Disulfiram-gold-nanorod integrate for effective tumor targeting and photothermal-chemical synergistic therapy
Herein, we successfully constructed a combination therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF).
Messenger RNA/polymeric carrier nanoparticles for delivery of heme oxygenase-1 gene in the post-ischemic brain
Heme oxygenase-1 messenger RNA (HO1-mRNA) was delivered into the post-ischemic brain, using a polymeric carrier. Therapeutic efficacy of HO1-mRNA delivery was compared with that of HO1-plasmid DNA (HO1-pDNA) in ischemia-reperfusion rat models.
Enhanced nanoparticle accumulation by tumor-acidity-activatable release of sildenafil to induce vasodilation
An efficient strategy to selectively promote nanoparticle accumulation in solid tumors was developed by encapsulating sildenafil in cisplatin-incorporated polymeric micelles.
Polydopamine-assisted one-step modification of nanofiber surfaces with adenosine to tune the osteogenic differentiation of mesenchymal stem cells and the maturation of osteoclasts
Adenosine and its receptors have emerged as alternative targets to control cellular functions for bone healing.
Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway
Novel carbon dots induced ER stress and activated PERK-eIF2α-ATF4 pathway promote bone regeneration.
Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper–tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer
Cu(TPZ)2 complex as a promising hypoxia selective cytotoxin in prostate cancer.
Novel anilino quinazoline-based EGFR tyrosine kinase inhibitors for treatment of non-small cell lung cancer
The two novel anilino quinazoline-based EGFR-TKIs have promising anti-tumor activity and limited hepatotoxicity, representing excellent candidates for combating the NSCLC.
A robust hybrid nanozyme@hydrogel platform as a biomimetic cascade bioreactor for combination antitumor therapy
The development of highly effective and minimally invasive approaches for cancer treatment is the ultimate goal.
A facile and universal strategy to endow implant materials with antibacterial ability via alkalinity disturbing bacterial respiration
A novel antibacterial strategy based on disturbing bacterial respiration was proposed, and we demonstrated a facile and universal method of magnetron sputtering alkaline magnesium oxide films to endow various implants with antibacterial ability.
About this collection
Welcome to our online rolling collection of the hottest work published in Biomaterials Science. Here we feature recent Biomaterials Science articles highlighted as HOT by the handling editor or our referees.
Congratulations to all the authors whose articles are featured.