Themed collection Biomaterials Science Recent HOT Articles

32 items
Review Article

The foreign body response: emerging cell types and considerations for targeted therapeutics

The emerging role of T cells, stromal cells, and senescent cells and their interactions with other cell types in the FBR are discussed in this review. Additionally, factors that modulate the phenotype of these cells are briefly considered.

Graphical abstract: The foreign body response: emerging cell types and considerations for targeted therapeutics
From the themed collection: Biomaterials Science Recent HOT Articles
Review Article

Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications

The CRISPR/Cas9 systems contain three modes: I. plasmid DNA encoding both Cas9 and sgRNA; II. Cas9 mRNA and sgRNA; III. Cas9 protein and sgRNA. We summarized the application of the synthesized nanomaterials for delivery the CRISPR/Cas9 systems.

Graphical abstract: Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications
From the themed collection: Biomaterials Science Recent HOT Articles
Review Article

Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing

Development of a novel biomaterial-based CRISPR-Cas9 system for the precise control of genome editing.

Graphical abstract: Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing
From the themed collection: Biomaterials Science Recent HOT Articles
Review Article

Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation

Nanomedicine recognition and clearance by the mononuclear phagocyte system (MPS) impedes optimal clinical impacts for this class of materials. We present an overview of factors involved in MPS interactions and approaches to overcome this barrier.

Graphical abstract: Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery

Alcohol solvents are encapsulated in palm oil-based microcapsules for the effective transdermal delivery of high-content actives.

Graphical abstract: Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery
From the themed collection: Biomaterials Science Recent HOT Articles
Open Access Paper

Synthetic hyaluronic acid coating preserves the phenotypes of lymphatic endothelial cells

Surface coating with dopamine conjugated hyaluronic acid (HA–DP) can interact with lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) to preserve the phenotypes and functionality of lymphatic endothelial cells (LECs).

Graphical abstract: Synthetic hyaluronic acid coating preserves the phenotypes of lymphatic endothelial cells
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Targeted microRNA delivery by lipid nanoparticles and gas vesicle-assisted ultrasound cavitation to treat heart transplant rejection

Despite exquisite immune response modulation, the extensive application of microRNA therapy in treating heart transplant rejection is still impeded by poor stability and low target efficiency.

Graphical abstract: Targeted microRNA delivery by lipid nanoparticles and gas vesicle-assisted ultrasound cavitation to treat heart transplant rejection
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Vaccine delivery by zwitterionic polysaccharide-based hydrogel microparticles showing enhanced immunogenicity and suppressed foreign body responses

The controlled release of antigens from zwitterionic-modified polysaccharide hydrogel microparticles has been actively pursued to achieve long-lasting immune responses in vaccine development.

Graphical abstract: Vaccine delivery by zwitterionic polysaccharide-based hydrogel microparticles showing enhanced immunogenicity and suppressed foreign body responses
From the themed collection: Biomaterials Science Recent HOT Articles
Open Access Paper

Does non-thermal plasma modify biopolymers in solution? A chemical and mechanistic study for alginate

The mutual interaction between reactive species generated by non-thermal plasma and biopolymers in solution causes oxidative modifications that can have an impact in biomedical applications.

Graphical abstract: Does non-thermal plasma modify biopolymers in solution? A chemical and mechanistic study for alginate
From the themed collection: Biomaterials Science Recent HOT Articles
Open Access Paper

Structural and mechanical properties of folded protein hydrogels with embedded microbubbles

Globular folded proteins are powerful building blocks to create biomaterials with mechanical robustness and inherent biological functionality.

Graphical abstract: Structural and mechanical properties of folded protein hydrogels with embedded microbubbles
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)

Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.

Graphical abstract: Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis

A smart skin regeneration platform that can enhance their selective cellular uptake to fibroblasts via PAR-2 receptor mediated endocytosis is proposed.

Graphical abstract: Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Tumor-targeting oxidative stress nanoamplifiers as anticancer nanomedicine with immunostimulating activity

GSH depleting prodrugs and ROS generators self-assemble to generate oxidative stress nanoamplifiers that can preferentially kill cancer cells and exert immunostimulating activity.

Graphical abstract: Tumor-targeting oxidative stress nanoamplifiers as anticancer nanomedicine with immunostimulating activity
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Photoclick polysaccharide-based bioinks with an extended biofabrication window for 3D embedded bioprinting

The proposed photoclick HC–HN bioink expands the palette of available polysaccharide-based bioinks and greatly extends the biofabrication window to broaden the application opportunities of 3D bioprinting.

Graphical abstract: Photoclick polysaccharide-based bioinks with an extended biofabrication window for 3D embedded bioprinting
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

In situ forming injectable γ-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control

An injectable adhesive hydrogel based on N-hydroxysuccinimide γ-poly(glutamic acid) and 4-armed poly(ethylene glycol) amine showed rapid gelation time, strong mechanical strength, satisfactory burst pressure and excellent hemostatic performance.

Graphical abstract: In situ forming injectable γ-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Flash nanotechnology-produced nanomedicines exhibit potent antioxidant and anti-inflammatory properties and could overcome mucosal barrier for oral delivery, resulting in great efficiency in the prevention and treatment of colitis-associated colorectal cancer.

Graphical abstract: Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

A component-optimized chemo-dynamic nanoagent for enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model

A component-optimized chemo-dynamic nanoagent achieved an enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model.

Graphical abstract: A component-optimized chemo-dynamic nanoagent for enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.

Graphical abstract: Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Functionalized boron nanosheets with near-infrared-triggered photothermal and nitric oxide release activities for efficient antibacterial treatment and wound healing promotion

A multifunctional nanoplatform has been developed based on boron nanosheets loaded quaternized chitosan and NO donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine for rapid, and effective treatment of pathogenic bacteria.

Graphical abstract: Functionalized boron nanosheets with near-infrared-triggered photothermal and nitric oxide release activities for efficient antibacterial treatment and wound healing promotion
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Plant-inspired Pluronic–gallol micelles with low critical micelle concentration, high colloidal stability, and protein affinity

Plant-inspired gallol-containing surfactants have been successfully incorporated into typical Pluronic® micelles, allowing low critical micelle concentration, great colloidal stability, and exterior enzyme resistance.

Graphical abstract: Plant-inspired Pluronic–gallol micelles with low critical micelle concentration, high colloidal stability, and protein affinity
From the themed collection: Biomaterials Science Recent HOT Articles
Open Access Paper

Enhanced human T cell expansion with inverse opal hydrogels

Lymph node-inspired 3D hydrogels with precisely defined porosity were produced, which improve the state-of-the-art T cell proliferation, a procedure that is especially important for novel cellular immunotherapies.

Graphical abstract: Enhanced human T cell expansion with inverse opal hydrogels
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid

The polymer dual drug conjugate synthesized by coupling docetaxel (DTX) and docosahexaenoic acid (DHA) with bifunctionalized dextran is selectively accumulated in tumor and nearly eradicates all MCF-7 tumors bearing in nude mice.

Graphical abstract: The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Fatty acid-based polymeric micelles to ameliorate amyloidogenic disorders

Fatty acid-tethered polymers were synthesized via RAFT method to explore their potential role in preventing insulin aggregation process. The results endowed fatty acid-tethered polymers with properties to act as novel anti-amyloidogenic agents.

Graphical abstract: Fatty acid-based polymeric micelles to ameliorate amyloidogenic disorders
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Tailored therapeutic release from polycaprolactone-silica hybrids for the treatment of osteomyelitis: antibiotic rifampicin and osteogenic silicates

Polycaprolactone/silica hybrids offer a dual therapeutic effect: the promotion of bone regeneration thanks to silicate ions and strong antibacterial properties against the risk of osteomyelitis.

Graphical abstract: Tailored therapeutic release from polycaprolactone-silica hybrids for the treatment of osteomyelitis: antibiotic rifampicin and osteogenic silicates
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Near-infrared aggregation-induced emission nanodots for early diagnosis of tongue squamous cell carcinoma and sentinel lymph node mapping

By developing DPA-TPE-DCM with intense near-infrared fluorescence emission in the aggregation state, AIE materials were used for the first time in the early diagnosis of orthotopic TSCC and SLN mapping in an orthotopic TSCC-bearing mouse model.

Graphical abstract: Near-infrared aggregation-induced emission nanodots for early diagnosis of tongue squamous cell carcinoma and sentinel lymph node mapping
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Development of anticancer peptides with low hemolysis, high penetrating membrane activity, certain analgesic activity and the synergistic anticancer effect

Amphiphilic cationic anticancer lipopeptide P10 self-assembles into spherical aggregates, which are used as drug carriers to play a synergistic anticancer role, and its anticancer mechanism is presented.

Graphical abstract: Development of anticancer peptides with low hemolysis, high penetrating membrane activity, certain analgesic activity and the synergistic anticancer effect
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Bionic biphasic composite scaffolds with osteochondrogenic factors for regeneration of full-thickness osteochondral defects

A bionic biphasic composite scaffold with on-demand osteochondrogenic factors facilitated the regeneration of osteochondral defects.

Graphical abstract: Bionic biphasic composite scaffolds with osteochondrogenic factors for regeneration of full-thickness osteochondral defects
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis

The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.

Graphical abstract: Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization

In this work, capillary tubes with different diameters were chosen to mimic a confined environment and the effect of space on the self-assembly behavior of short peptides with different oil-water partition coefficients (log P) was investigated.

Graphical abstract: Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

We have designed a dual-function microneedle patch that integrates treatment and diagnosis.

Graphical abstract: A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers

Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.

Graphical abstract: Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Medical gloves modified by a one-minute spraying process with blood-repellent, antibacterial and wound-healing abilities

A kind of blood-repellent mist spray (MS) was proposed to prevent blood adhesion during surgery and played an important role in antibacterial and wound-healing, which could be widely used in the surface modification of various medical gloves.

Graphical abstract: Medical gloves modified by a one-minute spraying process with blood-repellent, antibacterial and wound-healing abilities
From the themed collection: Biomaterials Science Recent HOT Articles
32 items

About this collection

Welcome to our online rolling collection of the hottest work published in Biomaterials Science. Here we feature recent Biomaterials Science articles highlighted as HOT by the handling editor or our referees.

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