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Themed collection Biomaterial Interactions with the Immune System

19 items
Communication

Immunomodulatory vasoactive intestinal peptide amphiphile micelles

Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found to directly correlate to anti-inflammatory behavior providing evidence that these biomaterials can serve as a promising new therapeutic modality.

Graphical abstract: Immunomodulatory vasoactive intestinal peptide amphiphile micelles
Open Access Correction

Correction: The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome

Editorial

Biomaterial interactions with the immune system

Guest editors Chris Jewell and Joel Collier introduce this Biomaterials Science themed issue on biomaterial interactions with the immune system.

Graphical abstract: Biomaterial interactions with the immune system
Communication

Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage

HA-based matrix spontaneously triggers M2-like polarity of human monocytes/macrophages through the CD44-mediated activation of STAT3.

Graphical abstract: Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage
Review Article

Polymeric micro- and nanoparticles for immune modulation

New advances in biomaterial-based approaches to modulate the immune system are being applied to treat cancer, infectious diseases, and autoimmunity.

Graphical abstract: Polymeric micro- and nanoparticles for immune modulation
Paper

Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice

Combined polyanhydride nanoparticles and pentablock copolymer micelles provide protection against homologous challenge in aged mice.

Graphical abstract: Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice
Paper

Response of macrophages and neural cells in contact with reduced graphene oxide microfibers

rGO microfibers mediate polarization of RAW-264.7 macrophages towards an M2 phenotype and support neural progenitor cell growth.

Graphical abstract: Response of macrophages and neural cells in contact with reduced graphene oxide microfibers
Paper

The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome

Polymers that are unable to escape the early endosome, and instead cause lysosomal rupture, activate the NLRP3 inflammasome.

Graphical abstract: The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome
Review Article

Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications

Layer-by-layer (LbL)-based biomaterials vaccines are broadly explored to tune the immunity in different diseases for translational purposes.

Graphical abstract: Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications
Open Access Paper

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

We sought to develop a nanoparticle vehicle that could deliver small molecule drugs to T cells.

Graphical abstract: Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles
Paper

External temperature control of lymphatic drainage of thermo-sensitive nanomaterials

External temperature control actively modulated the biodistribution of a thermo-sensitive nanomaterial among the injection site and the draining LNs.

Graphical abstract: External temperature control of lymphatic drainage of thermo-sensitive nanomaterials
Paper

Prussian blue nanoparticle-based antigenicity and adjuvanticity trigger robust antitumor immune responses against neuroblastoma

Photothermal therapy using CpG oligodeoxynucleotide-coated Prussian blue nanoparticles increases the tumor antigenicity and adjuvanticity, eliciting long-term tumor regression and immunological memory.

Graphical abstract: Prussian blue nanoparticle-based antigenicity and adjuvanticity trigger robust antitumor immune responses against neuroblastoma
Paper

Identifying key barriers in cationic polymer gene delivery to human T cells

Decreased uptake of polyplexes and an increased intracellular pH contribute to poor gene delivery to human T cells via cationic polymers.

Graphical abstract: Identifying key barriers in cationic polymer gene delivery to human T cells
Paper

Toward reducing biomaterial antigenic potential: a miniaturized Fc-binding domain for local deposition of antibodies

A novel bi-functional peptide consisting of an Fc-binding domain and self-assembly sequence is shown to retain IgG in vivo.

Graphical abstract: Toward reducing biomaterial antigenic potential: a miniaturized Fc-binding domain for local deposition of antibodies
Paper

In vivo targeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles

Gold nanoparticles functionalized with a thiol ligand containing both mannose mimicking shikimoyl- and transfection enhancing guanidinyl-functionalities for in vivo delivery of DNA vaccines to dendritic cells.

Graphical abstract: In vivo targeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles
Paper

Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis

A rapamycin-eluting PLLA-PCL stent is deployed into a diseased mouse trachea to treat laryngotracheal stenosis.

Graphical abstract: Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis
Minireview

Surgery-free injectable macroscale biomaterials for local cancer immunotherapy

Up-to-date review and perspective on injectable macroscale biomaterials for local cancer immunotherapy.

Graphical abstract: Surgery-free injectable macroscale biomaterials for local cancer immunotherapy
Paper

A chimeric, multivalent assembly of galectin-1 and galectin-3 with enhanced extracellular activity

Assembly of a fusion of galectin-1 and galectin-3 with higher carbohydrate binding affinity and a significantly lower effective dose than galectin-1.

Graphical abstract: A chimeric, multivalent assembly of galectin-1 and galectin-3 with enhanced extracellular activity
Paper

Engineering release kinetics with polyelectrolyte multilayers to modulate TLR signaling and promote immune tolerance

Degradable polyelectrolyle multilayers to enable controlled release of a regulatory toll-like receptor ligand to restrain inflammation and promote immune tolerance.

Graphical abstract: Engineering release kinetics with polyelectrolyte multilayers to modulate TLR signaling and promote immune tolerance
19 items

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