Biomaterial interactions with the immune system
Guest editors Chris Jewell and Joel Collier introduce this Biomaterials Science themed issue on biomaterial interactions with the immune system.
Surgery-free injectable macroscale biomaterials for local cancer immunotherapy
Up-to-date review and perspective on injectable macroscale biomaterials for local cancer immunotherapy.
Analyzing the scaffold immune microenvironment using flow cytometry: practices, methods and considerations for immune analysis of biomaterials
The immune system has evolved as a powerful tool for our body to combat infections, and is being engineered for new treatments in cancer, autoimmune disease, and trauma.
Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications
Layer-by-layer (LbL)-based biomaterials vaccines are broadly explored to tune the immunity in different diseases for translational purposes.
Polymeric micro- and nanoparticles for immune modulation
New advances in biomaterial-based approaches to modulate the immune system are being applied to treat cancer, infectious diseases, and autoimmunity.
Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage
HA-based matrix spontaneously triggers M2-like polarity of human monocytes/macrophages through the CD44-mediated activation of STAT3.
Immunomodulatory vasoactive intestinal peptide amphiphile micelles
Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found to directly correlate to anti-inflammatory behavior providing evidence that these biomaterials can serve as a promising new therapeutic modality.
Chitosan/poly(γ-glutamic acid) nanoparticles incorporating IFN-γ for immune response modulation in the context of colorectal cancer
This work highlights the potential synergistic effect of chitosan/γ-PGA nanoparticles with immunomodulatory cytokines, like IFN-γ, for anticancer therapy.
A chimeric, multivalent assembly of galectin-1 and galectin-3 with enhanced extracellular activity
Assembly of a fusion of galectin-1 and galectin-3 with higher carbohydrate binding affinity and a significantly lower effective dose than galectin-1.
Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis
A rapamycin-eluting PLLA-PCL stent is deployed into a diseased mouse trachea to treat laryngotracheal stenosis.
The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome
Polymers that are unable to escape the early endosome, and instead cause lysosomal rupture, activate the NLRP3 inflammasome.
Prussian blue nanoparticle-based antigenicity and adjuvanticity trigger robust antitumor immune responses against neuroblastoma
Photothermal therapy using CpG oligodeoxynucleotide-coated Prussian blue nanoparticles increases the tumor antigenicity and adjuvanticity, eliciting long-term tumor regression and immunological memory.
Engineering release kinetics with polyelectrolyte multilayers to modulate TLR signaling and promote immune tolerance
Degradable polyelectrolyle multilayers to enable controlled release of a regulatory toll-like receptor ligand to restrain inflammation and promote immune tolerance.
Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice
Combined polyanhydride nanoparticles and pentablock copolymer micelles provide protection against homologous challenge in aged mice.
Toward reducing biomaterial antigenic potential: a miniaturized Fc-binding domain for local deposition of antibodies
A novel bi-functional peptide consisting of an Fc-binding domain and self-assembly sequence is shown to retain IgG in vivo.
Identifying key barriers in cationic polymer gene delivery to human T cells
Decreased uptake of polyplexes and an increased intracellular pH contribute to poor gene delivery to human T cells via cationic polymers.
In vivo targeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles
Gold nanoparticles functionalized with a thiol ligand containing both mannose mimicking shikimoyl- and transfection enhancing guanidinyl-functionalities for in vivo delivery of DNA vaccines to dendritic cells.
External temperature control of lymphatic drainage of thermo-sensitive nanomaterials
External temperature control actively modulated the biodistribution of a thermo-sensitive nanomaterial among the injection site and the draining LNs.
Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles
We sought to develop a nanoparticle vehicle that could deliver small molecule drugs to T cells.
Response of macrophages and neural cells in contact with reduced graphene oxide microfibers
rGO microfibers mediate polarization of RAW-264.7 macrophages towards an M2 phenotype and support neural progenitor cell growth.