Themed collection Clinical Diagnostics
Analytical methods for clinical diagnostics
Guest Editors Salvador Garrigues and Miguel de la Guardia introduce the Clinical Diagnostics themed issue.
Vibrational spectroscopy for cancer diagnostics
The vibrational spectroscopy techniques of Raman spectroscopy and Fourier-transform infrared spectroscopy offer a number of potential advantages as tools for clinical diagnosis.
Cancer glycan biomarkers and their detection – past, present and future
Despite most of the known cancer biomarkers being glycoproteins, the full diagnostic potential of their glycan alterations remains largely untapped.
Nanomaterial-based electrochemical immunosensors as advanced diagnostic tools
We review recent advances made in the use of new nanomaterials for biosensing of different biomolecules, which have opened up new horizons in identifying and quantifying biomolecules, for possible early diagnosis of disease.
Metabolite fingerprint analysis of cervical cancer using LC-QTOF/MS and multivariate data analysis
The metabolic fingerprint of urine samples from women diagnosed with CC and control subjects were determined using LC coupled with Q-TOF/MS and independent variable analysis..
Determination of methylarginines in infant plasma by CE-LIF
Novel sample preparation and CE-LIF separation methods are described that can be implemented to quantify biomarkers of the nitric oxide metabolic pathway in plasma samples from critically ill infants.
A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements
An electrochemical biosensor for selective measurement of HDL-C in serum.
LOC-SERS: towards point-of-care diagnostic of methotrexate
Methotrexate (MTX), an antifolate antibiotic, is detected using a lab-on-a-chip device via surface enhanced Raman spectroscopy (LOC-SERS) in the therapeutic range of 10 μm to 0.1 μm.
Determination of biochemical parameters in human serum by near-infrared spectroscopy
NIR offers multiple advantages for serum analysis, permitting a fast and direct determination of several parameters simultaneously, with low sample handling and without the need for reagents during the measurement step.
Quantification of total serum transferrin and transferrin sialoforms in human serum; an alternative method for the determination of carbohydrate-deficient transferrin in clinical samples
Carbohydrate deficient transferrin (CDT) is a biochemical marker for congenital disorders of glycosylation (CDG), chronic alcohol consumption, and forensic medicine diagnosis.
Locating microcalcifications in breast histopathology sections using micro CT and XRF mapping
Systematic methods to identify the location of microcalcifications in histopathology sections assist in the study of these clinically important entities.
Investigating the use of Raman and immersion Raman spectroscopy for spectral histopathology of metastatic brain cancer and primary sites of origin
Raman and immersion Raman spectroscopy for diagnosing metastatic brain cancer and identifying primary sites of origin using brain tissue.
About this collection
This is a collection of papers highlighting important developments and novel applications in the area of clinical diagnostics. Guest Edited by Miguel de la Guardia and Salvador Garrigues. New articles will be added to this collection as they are published.