Themed collection Clinical Diagnostics

Guest Editors Salvador Garrigues and Miguel de la Guardia introduce the Clinical Diagnostics themed issue.

The vibrational spectroscopy techniques of Raman spectroscopy and Fourier-transform infrared spectroscopy offer a number of potential advantages as tools for clinical diagnosis.

Despite most of the known cancer biomarkers being glycoproteins, the full diagnostic potential of their glycan alterations remains largely untapped.

We review recent advances made in the use of new nanomaterials for biosensing of different biomolecules, which have opened up new horizons in identifying and quantifying biomolecules, for possible early diagnosis of disease.

The metabolic fingerprint of urine samples from women diagnosed with CC and control subjects were determined using LC coupled with Q-TOF/MS and independent variable analysis..

Novel sample preparation and CE-LIF separation methods are described that can be implemented to quantify biomarkers of the nitric oxide metabolic pathway in plasma samples from critically ill infants.

An electrochemical biosensor for selective measurement of HDL-C in serum.

Methotrexate (MTX), an antifolate antibiotic, is detected using a lab-on-a-chip device via surface enhanced Raman spectroscopy (LOC-SERS) in the therapeutic range of 10 μm to 0.1 μm.

NIR offers multiple advantages for serum analysis, permitting a fast and direct determination of several parameters simultaneously, with low sample handling and without the need for reagents during the measurement step.

Carbohydrate deficient transferrin (CDT) is a biochemical marker for congenital disorders of glycosylation (CDG), chronic alcohol consumption, and forensic medicine diagnosis.

Systematic methods to identify the location of microcalcifications in histopathology sections assist in the study of these clinically important entities.

Raman and immersion Raman spectroscopy for diagnosing metastatic brain cancer and identifying primary sites of origin using brain tissue.