Themed collection Biomedical Raman Imaging

16 items
Open Access Minireview

Recent advances in the use of stimulated Raman scattering in histopathology

Stimulated Raman histopathology with computer aided diagnosis.

Graphical abstract: Recent advances in the use of stimulated Raman scattering in histopathology
From the themed collection: Recent Review Articles
Tutorial Review

Raman microscopy for skin evaluation

The applications of Raman microscopies, such as spontaneous Raman scattering microscopy and coherent Raman scattering microscopy, used to evaluate skin and research trends are presented.

Graphical abstract: Raman microscopy for skin evaluation
From the themed collection: Recent Review Articles
Open Access Critical Review

Translational biophotonics with Raman imaging: clinical applications and beyond

The technological developments of high-speed spontaneous and coherent Raman scattering based imaging for translational applications including surgical guidance, histopathology, and pathophysiological monitoring.

Graphical abstract: Translational biophotonics with Raman imaging: clinical applications and beyond
From the themed collection: Biomedical Raman Imaging
Open Access Critical Review

Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery

Selective-sampling Raman Imaging enables intraoperative assessment of excised surgical margins in cancer surgery, a review.

Graphical abstract: Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery
From the themed collection: Recent Review Articles
Communication

Visualizing intra-medulla lipids in human hair using ultra-multiplex CARS, SHG, and THG microscopy

We performed label-free imaging of human-hair medulla using multi-modal nonlinear optical microscopy.

Graphical abstract: Visualizing intra-medulla lipids in human hair using ultra-multiplex CARS, SHG, and THG microscopy
From the themed collection: Biomedical Raman Imaging
Paper

DO-SRS imaging of metabolic dynamics in aging Drosophila

Emerging studies have shown that lipid metabolism plays an important role in aging.

Graphical abstract: DO-SRS imaging of metabolic dynamics in aging Drosophila
From the themed collection: Biomedical Raman Imaging
Paper

High spatial-resolution imaging of label-free in vivo protein aggregates by VISTA

High spatial-resolution label-free imaging of in vivo protein aggregates by VISTA for studying the details of amyloid-β plaque morphologies was achieved. Highly multiplex volumetric imaging was achieved by coupling VISTA imaging with U-net feature prediction.

Graphical abstract: High spatial-resolution imaging of label-free in vivo protein aggregates by VISTA
From the themed collection: Biomedical Raman Imaging
Paper

Detecting nitrile-containing small molecules by infrared photothermal microscopy

We demonstrated IR photothermal imaging of trifluoromethoxy carbonyl cyanide phenylhydrazone (FCCP) in cells. The result indicates that a nitrile group can be used as a vibrational tag to image target molecules.

Graphical abstract: Detecting nitrile-containing small molecules by infrared photothermal microscopy
From the themed collection: Biomedical Raman Imaging
Open Access Paper

Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy

Quantitative hyperspectral coherent Raman scattering microscopy merges imaging with spectroscopy and utilises quantitative data analysis algorithms to extract chemical components, spectrally and spatially-resolved, with sub-cellular resolution.

Graphical abstract: Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy
From the themed collection: Biomedical Raman Imaging
Paper

Multicolour chemical imaging of plant tissues with hyperspectral stimulated Raman scattering microscopy

Stimulated Raman scattering microscopy allows for multicolour label-free chemical imaging of plant tissues.

Graphical abstract: Multicolour chemical imaging of plant tissues with hyperspectral stimulated Raman scattering microscopy
From the themed collection: Biomedical Raman Imaging
Paper

Label-free Raman mapping of saturated and unsaturated fatty acid uptake, storage, and return toward baseline levels in macrophages

We use Raman imaging and analysis to evaluate the effects of different fatty acids following their uptake in macrophages, evaluating the fatty acid dynamics, endogenous cellular behavior and metabolism.

Graphical abstract: Label-free Raman mapping of saturated and unsaturated fatty acid uptake, storage, and return toward baseline levels in macrophages
From the themed collection: Biomedical Raman Imaging
Paper

Coherent anti-Stokes Raman scattering imaging of microcalcifications associated with breast cancer

Chemical imaging of calcifications was demonstrated in the depth of a tissue.

Graphical abstract: Coherent anti-Stokes Raman scattering imaging of microcalcifications associated with breast cancer
From the themed collection: Biomedical Raman Imaging
Open Access Paper

Self-absorption corrected non-invasive transmission Raman spectroscopy (of biological tissue)

Higher contrast of subsurface Raman spectra is achievable with self-absorption corrected transmission Raman spectroscopy. (Desired signal in red, interfering matrix artefacts in blue.)

Graphical abstract: Self-absorption corrected non-invasive transmission Raman spectroscopy (of biological tissue)
From the themed collection: Biomedical Raman Imaging
Paper

Nondestructive molecular imaging by Raman spectroscopy vs. marker detection by MALDI IMS for an early diagnosis of HCC

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide with a steadily increasing mortality rate.

Graphical abstract: Nondestructive molecular imaging by Raman spectroscopy vs. marker detection by MALDI IMS for an early diagnosis of HCC
From the themed collection: Biomedical Raman Imaging
Open Access Paper

Non-invasive depth determination of inclusion in biological tissues using spatially offset Raman spectroscopy with external calibration

Spatially Offset Raman Spectroscopy (SORS) allows chemical characterisation of biological tissues at depths enabling in vivo localization of biomarkers for early disease diagnosis.

Graphical abstract: Non-invasive depth determination of inclusion in biological tissues using spatially offset Raman spectroscopy with external calibration
From the themed collection: Biomedical Raman Imaging
Open Access Paper

Characterisation of estrogen receptor alpha (ERα) expression in breast cancer cells and effect of drug treatment using targeted nanoparticles and SERS

Targeted nanoparticles combined with surface enhanced Raman scattering (SERS) are used to characterise the estrogen receptor alpha (ERα) expression levels in breast cancer cells and the effect that SERD drug treatment has on these expression levels.

Graphical abstract: Characterisation of estrogen receptor alpha (ERα) expression in breast cancer cells and effect of drug treatment using targeted nanoparticles and SERS
From the themed collection: Biomedical Raman Imaging
16 items

About this collection

Raman spectroscopy has offered the potential as an optical biomedical imaging technique for many years due to the high molecular specificity, but has suffered from lack of sensitivity and the time taken for the measurements. Recent advances in instrumentation and variants on the technique such as SRS and CARS have addressed some of the limitations of the technique for biomedical imaging. This collection highlights advances in Raman spectroscopy aimed at improving the biomedical imaging capabilities and utility.

This collection is guest edited by Paola Borri (Cardiff University, UK), Katsumasa Fujita (Osaka University, Japan) and 

Analyst 

Advisory Board Member Wei Min (Columbia University, USA).

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