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Themed collection Bioanalytical tools for enabling precision medicine

15 items
Critical Review

Raman spectroscopy for rapid intra-operative margin analysis of surgically excised tumour specimens

A review of the progress and remaining challenges to the application of Raman spectroscopy for intraoperative margin analysis in cancer.

Graphical abstract: Raman spectroscopy for rapid intra-operative margin analysis of surgically excised tumour specimens
Critical Review

Towards precision medicine: the role and potential of protein and peptide microarrays

Techniques to comprehensively analyze protein signatures are pivotal to unravel disease mechanisms, develop novel biomarkers and targeted therapies. In this frame, protein and peptide microarrays can play a major role in fuelling precision medicine.

Graphical abstract: Towards precision medicine: the role and potential of protein and peptide microarrays
Paper

Engineering anisotropic cardiac monolayers on microelectrode arrays for non-invasive analyses of electrophysiological properties

Engineering cardiac tissues with physiological architectural and mechanical properties on microelectrode arrays enables long term culture and non-invasive collection of electrophysiological readouts.

Graphical abstract: Engineering anisotropic cardiac monolayers on microelectrode arrays for non-invasive analyses of electrophysiological properties
Paper

Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor

A nanofluidic mixing-enhanced biosensor enables parallel detection of soluble PD-1, PD-L1, and LAG-3 immune checkpoints in minute liquid biopsy samples.

Graphical abstract: Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
Accepted Manuscript - Paper

Vibrational spectroscopy as a powerful tool to follow-up immunoadsorption therapy treatment of dilated cardiomyopathy - a case report

Paper

CARS-imaging guidance for fs-laser ablation precision surgery

Ultrafast optical tools for disease diagnostics and precision surgery.

Graphical abstract: CARS-imaging guidance for fs-laser ablation precision surgery
Paper

Expression pattern of androgen receptors, AR-V7 and AR-567es, in circulating tumor cells and paired plasma-derived extracellular vesicles in metastatic castration resistant prostate cancer

Androgen-receptor splice variant 7 (AR-V7) is a highly promising liquid biopsy predictive biomarker showing primary or acquired resistance to novel androgen receptor signaling inhibitors in metastatic castration resistant prostate cancer (mCRPC).

Graphical abstract: Expression pattern of androgen receptors, AR-V7 and AR-567es, in circulating tumor cells and paired plasma-derived extracellular vesicles in metastatic castration resistant prostate cancer
Paper

Metabolomics for improved treatment monitoring of phenylketonuria: urinary biomarkers for non-invasive assessment of dietary adherence and nutritional deficiencies

Improved treatment monitoring of PKU patients: urinary biomarkers of dietary adherence and nutritional status.

Graphical abstract: Metabolomics for improved treatment monitoring of phenylketonuria: urinary biomarkers for non-invasive assessment of dietary adherence and nutritional deficiencies
Paper

SERS-based immunoassay using gold-patterned array chips for rapid and sensitive detection of dual cardiac biomarkers

A gold-patterned array platform has been developed for the ultrasensitive SERS-based detection of cTnI and CK-MB.

Graphical abstract: SERS-based immunoassay using gold-patterned array chips for rapid and sensitive detection of dual cardiac biomarkers
Paper

Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS

The ability of secondary ion mass spectrometry (SIMS) to provide high sensitivity imaging of elements and small-medium mass molecules in biological tissues and cells, makes it a very powerful tool for drug distribution studies.

Graphical abstract: Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS
Paper

Multiplex isolation and profiling of extracellular vesicles using a microfluidic DICE device

We present a simple strategy to immobilize and analyze extracellular vesicles for multiple markers on a microfluidic device, called DICE.

Graphical abstract: Multiplex isolation and profiling of extracellular vesicles using a microfluidic DICE device
Paper

A novel “AIE + ESIPT” near-infrared nanoprobe for the imaging of γ-glutamyl transpeptidase in living cells and the application in precision medicine

Novel near-infrared nanoprobe for detecting GGT in HepG2 cells and imaging in liver tumour tissue, satisfying for the need for clinical measure of GGT level.

Graphical abstract: A novel “AIE + ESIPT” near-infrared nanoprobe for the imaging of γ-glutamyl transpeptidase in living cells and the application in precision medicine
Paper

An electrochemical scaffold sensor for rapid syphilis diagnosis

The faster a disease is diagnosed, the sooner treatment can be initiated, motivating a drive to replace standard laboratory techniques with point-of-care technology. Here we describe the development of an E-DNA sensor for the rapid measurement of anti-syphilis antibodies.

Graphical abstract: An electrochemical scaffold sensor for rapid syphilis diagnosis
Paper

Ultrasensitive detection of lung cancer-associated miRNAs by multiple primer-mediated rolling circle amplification coupled with a graphene oxide fluorescence-based (MPRCA-GO) sensor

MPRCA-GO sensor can detect low amount of miRNAs, which are biomarkers in cancer diagnosis.

Graphical abstract: Ultrasensitive detection of lung cancer-associated miRNAs by multiple primer-mediated rolling circle amplification coupled with a graphene oxide fluorescence-based (MPRCA-GO) sensor
From the themed collection: Analyst Emerging Investigators
Paper

A new method using machine learning for automated image analysis applied to chip-based digital assays

An automated machine learning based method for image processes applied to digital assays.

Graphical abstract: A new method using machine learning for automated image analysis applied to chip-based digital assays
15 items

About this collection

A collection of papers and reviews on bioanalytical tools for enabling precision medicine. The field of healthcare continues to move from the inefficient, one-size-fits-all-patients medicine of today, toward the data-driven and personalised medicine of tomorrow. Articles in this collection cover bioanalytical tools for enabling precision medicine, including imaging, spectroscopy, machine learning and miniaturised technologies on both solid tumours and liquid biopsy samples. The focus of this collection is not limited to cancer but is relevant to other diseases such as cystic fibrosis, diabetes and infectious diseases.

This collection is co-guest edited by Analyst Advisory Board member Professor Steven Soper (The University of Kansas, Lawrence, USA) and Professor Andrew Godwin (Director, Molecular Oncology, The University of Kansas Medical Center, USA).

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