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Issue 18, 2019
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Towards precision medicine: the role and potential of protein and peptide microarrays

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Abstract

Although the traditional strategy of developing general medical treatments for heterogeneous patient populations has a well-established track record, the acknowledgment that one-size-does-not-fit-all is pushing health-care to enter a new era of tailored interventions. The advent of precision medicine is fueled by the high-throughput analysis of individual DNA variants and mRNA expression profiles. However, due to the role of proteins in providing a more direct view of disease states than genomics alone, the ability to comprehensively analyze protein alterations and post translational modifications (PTMs) is a necessary step to unravel disease mechanisms, develop novel biomarkers and targeted therapies. Protein and peptide microarrays can play a major role in this frame, due to high-throughput, low sample consumption and wide applicability. Here, their current role and potentialities are discussed through the review of some promising applications in the fields of PTMs analysis, enzyme screening, high-content immune-profiling and the phenotyping of extracellular vesicles.

Graphical abstract: Towards precision medicine: the role and potential of protein and peptide microarrays

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Article information


Submitted
21 Jun 2019
Accepted
27 Jul 2019
First published
31 Jul 2019

Analyst, 2019,144, 5353-5367
Article type
Critical Review

Towards precision medicine: the role and potential of protein and peptide microarrays

D. Brambilla, M. Chiari, A. Gori and M. Cretich, Analyst, 2019, 144, 5353
DOI: 10.1039/C9AN01142K

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