One-pot catalytic oxidation for the synthesis of 2-biphenylbenzoxazoles, benzothiazoles and 1-substituted benzimidazoles: a convenient and efficient strategy

Yifan Ouyang; Niuniu Zhang; Mingkang Yang; Hao Yang; Bei Jiang; Huilong Xie; Meimei Zhang

doi:10.1039/D5RA08212A

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One-pot catalytic oxidation for the synthesis of 2-biphenylbenzoxazoles, benzothiazoles and 1-substituted benzimidazoles: a convenient and efficient strategy

Yifan Ouyang,

^a Niuniu Zhang,^abc Mingkang Yang,^ac Hao Yang,

^b Bei Jiang,*^ad Huilong Xie*^a and Meimei Zhang*^b

Author affiliations

* Corresponding authors

^a Fujian Key Laboratory of Toxicant and Drug Toxicology, School of Medicine, Ningde Normal University, Ningde, Fujian 352100, PR China
E-mail: dalinorthjiang@163.com, T1236@ndnu.edu.cn

^b School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, PR China
E-mail: zhangmm196@163.com

^c College of Chemistry, Fuzhou University, Fuzhou 350100, PR China

^d Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, College of Pharmacy, Dali University, Dali, PR China

Abstract

We report a one-pot, catalytic oxidative synthesis of 2-biphenylbenzoxazoles, benzothiazoles and 1-substituted benzimidazoles from 2-aminosubstituted phenols/thiophenols/phenylamines and substituted biphenylcarbaldehydes. Among the advantages of this method are its simple procedure, high efficiency, and broad substrate scope.

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Article information

DOI: https://doi.org/10.1039/D5RA08212A
Article type: Paper
Submitted: 26 Oct 2025
Accepted: 05 Jan 2026
First published: 15 Jan 2026
This article is Open Access

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RSC Adv., 2026,16, 3527-3533

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One-pot catalytic oxidation for the synthesis of 2-biphenylbenzoxazoles, benzothiazoles and 1-substituted benzimidazoles: a convenient and efficient strategy

Y. Ouyang, N. Zhang, M. Yang, H. Yang, B. Jiang, H. Xie and M. Zhang, RSC Adv., 2026, 16, 3527 DOI: 10.1039/D5RA08212A

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One-pot catalytic oxidation for the synthesis of 2-biphenylbenzoxazoles, benzothiazoles and 1-substituted benzimidazoles: a convenient and efficient strategy

Abstract

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One-pot catalytic oxidation for the synthesis of 2-biphenylbenzoxazoles, benzothiazoles and 1-substituted benzimidazoles: a convenient and efficient strategy

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