I2-DMSO mediated oxidative amidation of methyl ketones with anthranils for the synthesis of α-ketoamides†
Abstract
An I2-DMSO mediated oxidative amidation of methyl ketones using anthranils as masked N-nucleophiles has been developed for the direct synthesis of α-ketoamides with high atom-economy. This metal-free process involves reductive N–O bond cleavage of anthranils and oxidative C–N bond formation of methyl ketones under mild conditions. The iodo group and electrophilic formyl group provide multiple possibilities for further functionalization of α-ketoamides.
- This article is part of the themed collection: Synthetic methodology in OBC