Issue 19, 2021

Domino Heck/Hiyama cross-coupling: trapping of the σ-alkylpalladium intermediate with arylsilanes

Abstract

A palladium-catalyzed domino Heck cyclization/Hiyama coupling reaction by the trapping of the σ-alkylpalladium intermediate with arylsilanes is described. A wide range of aryl-tethered alkenes and arylsilanes are all compatible with the reaction conditions. This approach shows good yields and excellent functional group tolerance, presenting a more practical and sustainable alternative to the conventional domino Heck cyclization/Suzuki coupling reaction.

Graphical abstract: Domino Heck/Hiyama cross-coupling: trapping of the σ-alkylpalladium intermediate with arylsilanes

Supplementary files

Article information

Article type
Communication
Submitted
29 Mar 2021
Accepted
16 Apr 2021
First published
16 Apr 2021

Org. Biomol. Chem., 2021,19, 4254-4257

Domino Heck/Hiyama cross-coupling: trapping of the σ-alkylpalladium intermediate with arylsilanes

X. Wu, H. Ye, G. Jiang and L. Hu, Org. Biomol. Chem., 2021, 19, 4254 DOI: 10.1039/D1OB00595B

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