Issue 19, 2021
From the journal:

Organic & Biomolecular Chemistry

Transition-metal-free oxidative cyclization reaction of enynals to access pyrane-2-one derivatives†

Farzaneh Ansari,ab   Hormoz Khosravi, ORCID logo b   Alireza Abbasi Kejani,b   Mahsa Armaghan,c   Walter Frank,c   Saeed Balalaie ORCID logo *bd  and  Farnaz Jafarpour ORCID logo *a  

* Corresponding authors

a School of Chemistry, College of Science, University of Tehran, Tehran 14155-6455, Iran
E-mail: Jafarpur@khayam.ut.ac.ir

b Peptide Chemistry Research Institute, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran
E-mail: balalaie@kntu.ac.ir

c Institut für Anorganische Chemie und Strukturchemie, Heinrich–Heine–Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany

d Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract

A novel and efficient metal-free C–H functionalization of enynals is developed to synthesize α-pyrone derivatives via the formation of two C–O bonds. In this project, K2S2O8 has been introduced as an efficient oxygen source and C–H functionalization agent in regioselective oxidative cyclization reaction with a relatively broad substrate scope.

Graphical abstract: Transition-metal-free oxidative cyclization reaction of enynals to access pyrane-2-one derivatives

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Article information

DOI
https://doi.org/10.1039/D1OB00726B
Article type
Communication
Submitted
14 Apr 2021
Accepted
20 Apr 2021
First published
20 Apr 2021

Org. Biomol. Chem., 2021,19, 4263-4267

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Transition-metal-free oxidative cyclization reaction of enynals to access pyrane-2-one derivatives

F. Ansari, H. Khosravi, A. Abbasi Kejani, M. Armaghan, W. Frank, S. Balalaie and F. Jafarpour, Org. Biomol. Chem., 2021, 19, 4263 DOI: 10.1039/D1OB00726B

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