A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays.
E. T. T. Lee, Y. Sato and S. Nishizawa, Chem. Commun., 2020, 56, 14976 DOI: 10.1039/D0CC06084D
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