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Elastase-triggered H2S delivery from polymer hydrogels

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Abstract

We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.

Graphical abstract: Elastase-triggered H2S delivery from polymer hydrogels

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Article information


Submitted
08 Nov 2019
Accepted
16 Dec 2019
First published
02 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Elastase-triggered H2S delivery from polymer hydrogels

M. Zhou, Y. Qian, Y. Zhu and J. Matson, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08752D

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