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Copper-catalyzed direct C–H phosphorylation of N-imino isoquinolinium ylides with H-phosphonates

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Abstract

A new and efficient protocol for the synthesis of phosphorus-containing isoquinoline skeletons via copper-catalyzed direct C–H phosphorylation of N-iminoisoquinolinium ylides with H-phosphonates has been described. A variety of N-iminoisoquinolinium ylides reacted under the ligand and oxidant free conditions smoothly to afford phosphorylated isoquinolines in moderate to excellent yields.

Graphical abstract: Copper-catalyzed direct C–H phosphorylation of N-imino isoquinolinium ylides with H-phosphonates

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Publication details

The article was received on 23 Jan 2019, accepted on 13 Mar 2019 and first published on 15 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00107G
Citation: Org. Chem. Front., 2019, Advance Article

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    Copper-catalyzed direct C–H phosphorylation of N-imino isoquinolinium ylides with H-phosphonates

    X. Zhan, Y. Hei, J. Song, P. Qian, X. Zhang and C. Deng, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00107G

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