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Ruthenium(II)-catalyzed C–O/C–S cyclization for the synthesis of 5-membered O-containing and S-containing heterocycles

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Abstract

An efficient and convenient method for the synthesis of oxazole derivatives from enamides has been established via a ruthenium-catalyzed C–O cyclization. This protocol allows for a wide functional group compatibility, broad substrate scope and ease of operation. This catalytic method is also applicable to other 5-membered O-containing and S-containing heterocyclic systems involving thiazole and furan scaffolds, thus this strategy can be broadly applied to organic synthesis and medicinal chemistry.

Graphical abstract: Ruthenium(ii)-catalyzed C–O/C–S cyclization for the synthesis of 5-membered O-containing and S-containing heterocycles

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Publication details

The article was received on 30 Dec 2018, accepted on 31 Jan 2019 and first published on 06 Feb 2019


Article type: Research Article
DOI: 10.1039/C8QO01425F
Citation: Org. Chem. Front., 2019, Advance Article

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    Ruthenium(II)-catalyzed C–O/C–S cyclization for the synthesis of 5-membered O-containing and S-containing heterocycles

    J. Liu, Y. Wen, F. He, L. Gao, L. Gao, J. Wang, X. Wang, Y. Zhang and L. Hu, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01425F

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