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Catalyst-Free Regioselective Hydroxyfluorination and Aminofluorination of α, β-Unsaturated Ketones

Abstract

The catalyst-free direct regioselective α-fluoro-β-hydroxylation and α-fluoro-β-amidation of α, β-unsaturated ketones has been developed. Various α, β-unsaturated ketones react with Selectfluor in water and acetonitrile to give α-fluorohydrins and α-fluoroamides respectively with moderate to good yield. The mechanistic studies revealed the possibility of a radical based pathway.

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Publication details

The article was received on 25 Feb 2019, accepted on 15 Apr 2019 and first published on 16 Apr 2019


Article type: Communication
DOI: 10.1039/C9OB00467J
Citation: Org. Biomol. Chem., 2019, Accepted Manuscript

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    Catalyst-Free Regioselective Hydroxyfluorination and Aminofluorination of α, β-Unsaturated Ketones

    J. Zhou, Y. Fang, F. Wang and J. Li, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB00467J

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