Palladium catalyzed chemo- and site-selective C–H acetoxylation and hydroxylation of oxobenzoxazine derivatives

Abstract

An efficient protocol for the introduction of acetoxy and hydroxy functionalities on unactivated aryl sp² carbons of oxobenzoxazine derivatives via an ortho-C–H activation reaction using a palladium catalyst has been developed for the first time. Interestingly, this intermolecular C–H functionalization reaction takes place in a facile and simple manner with high chemo- and site selectivity.