Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 5, 2019
Previous Article Next Article

Solution-phase total synthesis of teixobactin

Author affiliations


The first solution-phase total synthesis of the cyclic depsipeptide teixobactin is described. Stereoselective construction of L-allo-enduracididine was established, and the protective groups for the peptide coupling reactions and conditions for the assembly of the fragments were also optimised. The longest linear sequence for the total synthesis was 20 steps from the known L-cis-4-hydroxyproline derivative and gave a 5.6% overall yield. This solution-phase total synthesis could serve as a complement to the current solid-phase synthesis of teixobactin.

Graphical abstract: Solution-phase total synthesis of teixobactin

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Nov 2018, accepted on 02 Jan 2019 and first published on 03 Jan 2019

Article type: Paper
DOI: 10.1039/C8OB02803F
Org. Biomol. Chem., 2019,17, 1141-1153

  •   Request permissions

    Solution-phase total synthesis of teixobactin

    B. Gao, S. Chen, Y. N. Hou, Y. J. Zhao, T. Ye and Z. Xu, Org. Biomol. Chem., 2019, 17, 1141
    DOI: 10.1039/C8OB02803F

Search articles by author