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Cascade Knoevenagel and aza-Wittig reactions for the synthesis of substituted quinolines and quinolin-4-ols

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Abstract

A [4 + 2] annulation involving cascade Knoevenagel, aza-Wittig and dehydrofluorination reactions is developed for the synthesis of substituted quinolin-4-ols including analogs bearing CF2H, CF3, and C2F5 groups. This simple and highly efficient method is also applicable for the synthesis of substituted quinolines. A number of reported biologically active compounds can be readily prepared by this one-pot synthesis. Green chemistry metrics analysis of the new reaction processes provided favorable results.

Graphical abstract: Cascade Knoevenagel and aza-Wittig reactions for the synthesis of substituted quinolines and quinolin-4-ols

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Publication details

The article was received on 10 Oct 2018, accepted on 18 Dec 2018 and first published on 18 Dec 2018


Article type: Paper
DOI: 10.1039/C8GC03180K
Citation: Green Chem., 2019, Advance Article
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    Cascade Knoevenagel and aza-Wittig reactions for the synthesis of substituted quinolines and quinolin-4-ols

    X. Zhang, X. Ma, W. Qiu, J. Evans and W. Zhang, Green Chem., 2019, Advance Article , DOI: 10.1039/C8GC03180K

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