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Issue 27, 2019
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Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

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Abstract

A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal–organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest–host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation.

Graphical abstract: Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

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Supplementary files

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Submitted
20 Dec 2018
Accepted
18 Feb 2019
First published
18 Feb 2019

Chem. Commun., 2019,55, 3868-3871
Article type
Communication

Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

B. E. Souza, S. Rudić, K. Titov, A. S. Babal, J. D. Taylor and J. Tan, Chem. Commun., 2019, 55, 3868
DOI: 10.1039/C8CC10089F

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