Preparation of Graphene Oxide and their Application for Improving the Properties of the Electrochemical Sensor for the Determination of Bambuterol Hydrochloride in Real Samples
In this work, an ion selective electrode modifying with graphene oxide (GO) was developed to determinate BAM by electrochemical method. First of all, composites of electro-active complex and GO was prepared as GO@BAM-TPB through drop-by-drop operation under stirring circumstance. In the next step, a membrane solution for electrode was made by mixing GO@BAM-TPB and film-forming materials and the prepared membrane solution was dipped uniformly onto the surface of bare platinum electrode. A few days later, the modified electrode had been dried spontaneously at room temperature, that could be reserved for use. Adequate characterizations have been done including not only structure and morphology of materials but also electrochemical properties of the modified electrode. We discussed modifying outcomes in both structure and morphology aspects. The parameters of modified electrode were as follows: a lower LOD (3.4×10-7 mol/L), a wider response range (1.0×10-1 to 1.0×10-6 mol/L), and a smaller response time (15s) than the traditional electrodes. Moreover, the modified electrode exhibits good selectivity, reproducibility, lifetime (up to 12 weeks) and pH range (3.5-7.1). Finally, BAM selective electrode was employed for determining BAM in real samples (eg, swine urine), as results shows, it proved to be a reasonable method to the determination of BAM.