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Issue 48, 2018
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Ratiometric fluorescence probe for hydrazine vapor detection and biological imaging

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Abstract

Hydrazine (N2H4) has been widely applied in most of the chemical industry; however, it is now believed that it can cause serious damage to protein and nucleic acid upon ingestion. Herein we introduced a specially designed molecular probe 1, with an electron deficient lactone group as a specially designed reactive site and a naphthalimide fluorophore that is easily modified owing to lactone involvement. The free probe 1 exhibited blue fluorescence in neutral buffer owing to the low favorability of ICT (intramolecular charge transfer), while the specially designed lactone group could potentially undergo a ring-opening reaction with hydrazine, resulting in a favoured ICT effect and bathochromically shifted (125 nm) fluorescence response. The ratiometric fluorescence signal enabled quantitative determination of hydrazine using probe 1 in complex applications. Besides, probe 1 features a rapid signal response time (within 5 min) and low detection limit (36 nM) for hydrazine. Utilizing these excellent properties, probe 1 was further applied in hydrazine vapor detection and bio-imaging. Conceptually, we now present a new approach for the detection of hydrazine, and the enhanced performances of probe 1 will promote its applications in living systems and the environment.

Graphical abstract: Ratiometric fluorescence probe for hydrazine vapor detection and biological imaging

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Publication details

The article was received on 27 Sep 2018, accepted on 26 Oct 2018 and first published on 02 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB02536C
Citation: J. Mater. Chem. B, 2018,6, 8085-8089
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    Ratiometric fluorescence probe for hydrazine vapor detection and biological imaging

    W. Zhang, F. Huo, T. Liu and C. Yin, J. Mater. Chem. B, 2018, 6, 8085
    DOI: 10.1039/C8TB02536C

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