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Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light

Abstract

The integrating various theranostic modalities into one nanoplatform for combined treatment of tumor is highly demanded in biomedicine field. However, it is still challenging to engineer such a platform with good biocompatible, multifunctional and external stimuli response. Herein, biocompatible lipid bilayer modified mesoporous silica coated gold nanorods (AuNRs) nanocomposites were developed. The heating from the near-infrared (NIR)-stimulated AuNR cores could improve the permeability of lipid bilayer, leading to drug release. The in vitro results exhibited that the DOX loaded nanocomposites had high treatment efficiency of HeLa cells upon NIR irradiation. They may find potential in cancel treatment.

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Publication details

The article was received on 22 Jul 2018, accepted on 05 Nov 2018 and first published on 06 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB01891J
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light

    X. cui, W. Cheng and X. Han, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01891J

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