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Surface engineering of titanium implants with enzyme-triggered antibacterial property and enhanced osseointegration in vivo

Abstract

Preventing bacterial infection and improving osseointegration of titanium (Ti) and its alloys are both highly crucial factors for their long-term successful implantation in clinic applications. However, the straightforward applications of antibacterial surfaces on Ti-based materials remain limited owing to their side effects on cytocompatibility. Herein, catechol-functionalized multilayer films composed of dopamine-modified HA (HA-c) and 3, 4-dihydroxyhydrocinnamic acid-modified Chi (Chi-c) were developed on Ti substrates modified with TiO2 nanotube arrays loading of antibacterial drug. The treated Ti substrates showed strong hydrophilicity with the water contact angle about 20°, and obviously inhibited bacterial early-stage adhesion. Moreover, this system displayed an enzyme-responsive release of antibacterial drug triggered by the hyaluronidase degradation of HA-c, which exhibited the effective antibacterial ability and eliminated side effect caused by burst release of antibiotics. Meanwhile, the modified Ti substrates significantly promoted initial osteoblasts adhesion through up-regulating the expressions of adhesion related genes including integrin αv and β3. More importantly, this prepared coating with bacteria self-responsiveness improved osseointegration and prevented bacterial infection of Ti implants in vivo. Overall, our developed catechol-functionalized and bacterial self-responsive coating on Ti substrates has great significance in clinical applications of orthopedic and dental implants.

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Publication details

The article was received on 25 Jul 2018, accepted on 04 Nov 2018 and first published on 06 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB01918E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Surface engineering of titanium implants with enzyme-triggered antibacterial property and enhanced osseointegration in vivo

    Z. Yuan, S. Huang, S. Lan, H. Xiong, B. Tao, Y. Ding, Y. Liu, P. Liu and K. Cai, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01918E

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