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Construction of a novel near infrared fluorescent probe with multiple fluorescence emission and its application for SO2 derivative detection in cells and living zebrafish

Abstract

Sulfur dioxide (SO2) in biological system is an important gaseous signal molecule and plays important roles in physiological activities. It can be endogenously produced by enzymes in mitochondria during oxidation of sulphur-containing molecules. Thus development of probes for sulfur dioxide detection in biological environment is necessary. Herein, a new near infrared fluorescent probe (Rh-TPA) with multiple fluorescence emission was constructed and applied for SO2 derivative detection. Rh-TPA was constructed via conjugation of a rhodamine analogue structure with triphenylamine group. Rh-TPA exhibited a major emission peak at 740 nm and a shoulder peak at 810 nm. When interacted with SO2 derivatives, the conjugated system was transferred into two smaller separated chromophores with two emission peaks (520 nm and 570 nm) in visible region. The probe showed little cytotoxicity as proved by the MTT results. Biological imaging application experiments indicated that the probe can be used to image SO2 derivatives in HeLa cells and living zebrafish.

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Publication details

The article was received on 02 Aug 2018, accepted on 05 Oct 2018 and first published on 06 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB02030B
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Construction of a novel near infrared fluorescent probe with multiple fluorescence emission and its application for SO2 derivative detection in cells and living zebrafish

    K. Liu, Y. Chen, H. Sun, S. Wang and F. Kong, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02030B

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