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Issue 43, 2018
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3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

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Abstract

We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells’ proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

Graphical abstract: 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

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Publication details

The article was received on 04 Jul 2018, accepted on 13 Oct 2018 and first published on 15 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB01757C
Citation: J. Mater. Chem. B, 2018,6, 7066-7075
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    3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

    C. Xu, B. Zhang Molino, X. Wang, F. Cheng, W. Xu, P. Molino, M. Bacher, D. Su, T. Rosenau, S. Willför and G. Wallace, J. Mater. Chem. B, 2018, 6, 7066
    DOI: 10.1039/C8TB01757C

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