Issue 47, 2018

BSA-modified poly(pyrrole-3-carboxylic acid) nanoparticles as carriers for combined chemo-photothermal therapy

Abstract

A facile reverse microemulsion method was developed for the synthesis of homogenous poly(pyrrole-3-carboxylic acid) (PPyCOOH) nanoparticles, which used n-heptane as the oil phase, sodium dodecyl sulfate as the surfactant, 1-butanol as the co-surfactant and pyrrole-3-carboxylic solution as the aqueous phase. The obtained PPyCOOH nanoparticles had uniform sizes, high near-infrared absorption and abundant functional groups. To improve their stability and enhance the tumor inhibition rate, the PPyCOOH nanoparticles were modified with bovine serum albumin (BSA) and doxorubicin (DOX). The as-fabricated drug delivery system (DOX@BSA-PPyCOOH) combining photothermal therapy and chemotherapy exhibited pH-sensitive and near infrared laser controlled drug release, which was beneficial for drug enrichment in the tumor and for reducing the toxicity and side effects in normal tissue. Combined chemo-photothermal therapy in vivo revealed that the tumors were completely eliminated and no obvious toxicity was found in the major organs, suggesting that DOX@BSA-PPyCOOH nanoparticles are an efficient nanoagent for cancer treatment.

Graphical abstract: BSA-modified poly(pyrrole-3-carboxylic acid) nanoparticles as carriers for combined chemo-photothermal therapy

Article information

Article type
Paper
Submitted
25 Jul 2018
Accepted
19 Oct 2018
First published
06 Nov 2018

J. Mater. Chem. B, 2018,6, 7877-7888

BSA-modified poly(pyrrole-3-carboxylic acid) nanoparticles as carriers for combined chemo-photothermal therapy

X. Bi, H. Su, W. Shi, X. Liu, Z. He, X. Zhang, Y. Sun and D. Ge, J. Mater. Chem. B, 2018, 6, 7877 DOI: 10.1039/C8TB01921E

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