Jump to main content
Jump to site search

Issue 47, 2018
Previous Article Next Article

Facile preparation of biocompatible Ti2O3 nanoparticles for second near-infrared window photothermal therapy

Author affiliations

Abstract

Photothermal therapy (PTT) is emerging as a powerful tool for the treatment of cancer. However, typical photothermal agents are excited by conventional near-infrared light (NIR-I, 700–900 nm), which leads to low tissue penetration and significantly hinders their further application. Compared with NIR-I light, the second NIR optical window light (NIR-II, 1000–1700 nm) can remarkably increase the tissue penetration depth; however, photothermal agents in this optical window are extremely limited and need to be further explored. Herein, we prepared Ti2O3 nanoparticles through a ball milling method, and to further improve their biocompatibility and targeting efficiency, the Ti2O3 nanoparticles were modified with hyaluronic acid. The as-prepared nanoparticles exhibited strong light absorption and excellent photothermal conversion efficiency in the NIR-II optical window. Both in vitro and in vivo studies clearly demonstrated that the Ti2O3@HA nanoparticles not only exhibit high biocompatibility and photostability, but also can be efficiently taken up by cancer cells and display excellent anticancer ability in the NIR-II region. Thus, this study provides a novel photothermal agent for PTT in the NIR-II optical window, which may further advance cancer photo-treatment in future.

Graphical abstract: Facile preparation of biocompatible Ti2O3 nanoparticles for second near-infrared window photothermal therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Aug 2018, accepted on 29 Oct 2018 and first published on 29 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB02079E
Citation: J. Mater. Chem. B, 2018,6, 7889-7897
  •   Request permissions

    Facile preparation of biocompatible Ti2O3 nanoparticles for second near-infrared window photothermal therapy

    J. Zeng, M. Wu, S. Lan, J. Li, X. Zhang, J. Liu, X. Liu, Z. Wei and Y. Zeng, J. Mater. Chem. B, 2018, 6, 7889
    DOI: 10.1039/C8TB02079E

Search articles by author

Spotlight

Advertisements