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Simultaneous near-infrared and green fluorescence from single conjugated polymer dots with aggregation-induced emission fluorogen for cell imaging

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Abstract

Near-infrared fluorescent probes are important and interesting for advanced biological and biomedical applications where the fluorescence technology is employed. Herein, we reported high near-infrared (NIR) fluorescent conjugated polymer dots (Pdots) of two polymers (PTPE–DTNT2 and PTPE–DTNT4) with cross-conjugated aggregation-induced emission fluorogen as the side chain. The photoluminescent quantum yields (PLQYs) of Pdots were up to 31.8% with the near-infrared emission peak of 716 nm, which is among the best values of NIR Pdots reported so far. In addition, Pdots possessed a dual-color emission feature. Thus, dual-color cellular imaging with both Pdots was demonstrated in biological applications; to the best of our knowledge, this is the first reported dual-color cellular imaging with Pdots. The NIR Pdots were also applied in in vivo cytotoxicity analysis and microangiography imaging of zebrafish. We anticipate that NIR Pdots with their dual-color feature will find broad applications in multiplexed biological and biomedical fields.

Graphical abstract: Simultaneous near-infrared and green fluorescence from single conjugated polymer dots with aggregation-induced emission fluorogen for cell imaging

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Publication details

The article was received on 05 Sep 2018, accepted on 24 Oct 2018 and first published on 24 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB02346H
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Simultaneous near-infrared and green fluorescence from single conjugated polymer dots with aggregation-induced emission fluorogen for cell imaging

    S. Chen, S. Cui, R. Du, M. Liu, W. Tsai, F. Guo, Q. Wu, L. Zhao and Y. Zhang, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02346H

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