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Copper catalyzed one-pot difluoroalkylation and lactonization of unsaturated carboxylic acids

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Abstract

γ-Lactone is an important scaffold found in many natural products and biologically active compounds. A strategy for one-pot bi-functionalization of unsaturated carboxylic acids to afford difluoroalkylated γ-lactones using a Cu(I) catalyst has been reported. This protocol has the advantages of mild reaction conditions, a low-cost catalyst, and a broad substrate scope, which provides a convenient strategy for synthesizing various difluoroalkylated γ-lactones.

Graphical abstract: Copper catalyzed one-pot difluoroalkylation and lactonization of unsaturated carboxylic acids

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Publication details

The article was received on 30 Aug 2018, accepted on 05 Oct 2018 and first published on 06 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00940F
Citation: Org. Chem. Front., 2018, Advance Article
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    Copper catalyzed one-pot difluoroalkylation and lactonization of unsaturated carboxylic acids

    F. Yuan, S. Zhou, Y. Yang, M. Guo, X. Tang and G. Wang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00940F

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