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A facile approach to synthesize azaindoline functionalized spirocarbocyclic scaffolds via a Pd-catalyzed cascade cyclization/dearomatization process

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Abstract

A novel construction of azaindoline functionalized spirocarbocyclic scaffolds bearing two all-carbon quaternary centers has been developed via a palladium-catalyzed Heck cyclization/phenol dearomatization reaction. In the cascade process, three new C(sp2)–C(sp3) bonds are formed in a single chemical operation. The approach shows broad substrate scope and good functional-group tolerance.

Graphical abstract: A facile approach to synthesize azaindoline functionalized spirocarbocyclic scaffolds via a Pd-catalyzed cascade cyclization/dearomatization process

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Publication details

The article was received on 05 Sep 2018, accepted on 07 Oct 2018 and first published on 09 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00964C
Citation: Org. Chem. Front., 2018, Advance Article
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    A facile approach to synthesize azaindoline functionalized spirocarbocyclic scaffolds via a Pd-catalyzed cascade cyclization/dearomatization process

    X. Wu, H. Tian, Y. Wang, A. Liu, H. Chen, Z. Fan, X. Li and S. Chen, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00964C

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