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Facile construction of hydrogenated azepino[3,2,1-hi]indoles by Rh(III)-catalyzed C–H activation/[5 + 2] annulation of N-cyanoacetylindolines with sulfoxonium ylides

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Abstract

Rhodium(III)-catalyzed regio- and chemoselective [5 + 2] annulation between N-(cyanoacetyl)indolines and sulfoxonium ylides has been realized, leading to efficient construction of seven-membered rings under mild conditions. This reaction proceeded via C–H activation with sulfoxonium ylides as carbene synthons.

Graphical abstract: Facile construction of hydrogenated azepino[3,2,1-hi]indoles by Rh(iii)-catalyzed C–H activation/[5 + 2] annulation of N-cyanoacetylindolines with sulfoxonium ylides

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Publication details

The article was received on 11 Aug 2018, accepted on 01 Oct 2018 and first published on 10 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00861B
Citation: Org. Chem. Front., 2018, Advance Article
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    Facile construction of hydrogenated azepino[3,2,1-hi]indoles by Rh(III)-catalyzed C–H activation/[5 + 2] annulation of N-cyanoacetylindolines with sulfoxonium ylides

    P. Hu, Y. Zhang, B. Liu and X. Li, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00861B

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