Issue 22, 2018

Facile construction of hydrogenated azepino[3,2,1-hi]indoles by Rh(iii)-catalyzed C–H activation/[5 + 2] annulation of N-cyanoacetylindolines with sulfoxonium ylides

Abstract

Rhodium(III)-catalyzed regio- and chemoselective [5 + 2] annulation between N-(cyanoacetyl)indolines and sulfoxonium ylides has been realized, leading to efficient construction of seven-membered rings under mild conditions. This reaction proceeded via C–H activation with sulfoxonium ylides as carbene synthons.

Graphical abstract: Facile construction of hydrogenated azepino[3,2,1-hi]indoles by Rh(iii)-catalyzed C–H activation/[5 + 2] annulation of N-cyanoacetylindolines with sulfoxonium ylides

Supplementary files

Article information

Article type
Research Article
Submitted
11 Aug 2018
Accepted
01 Oct 2018
First published
10 Oct 2018

Org. Chem. Front., 2018,5, 3263-3266

Facile construction of hydrogenated azepino[3,2,1-hi]indoles by Rh(III)-catalyzed C–H activation/[5 + 2] annulation of N-cyanoacetylindolines with sulfoxonium ylides

P. Hu, Y. Zhang, B. Liu and X. Li, Org. Chem. Front., 2018, 5, 3263 DOI: 10.1039/C8QO00861B

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