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Photoredox-catalyzed indirect acyl radical generation from thioesters

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Abstract

A photoredox-catalyzed method for the indirect generation of acyl radicals from stable thioesters is described. The process is applicable to both aromatic and aliphatic substrates, and the resulting acyl radicals can undergo both intermolecular and intramolecular reactions. The mild reaction conditions allow for domino photoredox-catalyzed processes to occur. To illustrate the utility of the method, the total synthesis of a pharmaceutical agent is described.

Graphical abstract: Photoredox-catalyzed indirect acyl radical generation from thioesters

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Publication details

The article was received on 13 Aug 2018, accepted on 04 Oct 2018 and first published on 05 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00867A
Citation: Org. Chem. Front., 2018, Advance Article
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    Photoredox-catalyzed indirect acyl radical generation from thioesters

    A. R. Norman, M. N. Yousif and C. S. P. McErlean, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00867A

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