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Copper-catalyzed direct trifluoromethylthiolation of indoles by tert-butyl 2-((trifluoromethyl)sulfonyl)hydrazine-1-carboxylate

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Abstract

In this study, we developed the first copper-catalyzed direct trifluoromethylthiolation of indoles using TfNHNHBoc as a trifluoromethylthiolation reagent. Due to the cheap and readily accessible reagents, as well as its mild reaction conditions and good atom economy, this method is as an alternative and practical strategy for trifluoromethylthiolation of indoles.

Graphical abstract: Copper-catalyzed direct trifluoromethylthiolation of indoles by tert-butyl 2-((trifluoromethyl)sulfonyl)hydrazine-1-carboxylate

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Publication details

The article was received on 28 Jul 2018, accepted on 14 Sep 2018 and first published on 15 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00779A
Citation: Org. Chem. Front., 2018, Advance Article
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    Copper-catalyzed direct trifluoromethylthiolation of indoles by tert-butyl 2-((trifluoromethyl)sulfonyl)hydrazine-1-carboxylate

    K. Lu, Q. Li, X. Xi, Y. Huang, Z. Gong, P. Yu and X. Zhao, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00779A

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