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Issue 21, 2018
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Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform

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Abstract

The direct dearomatization reaction of isoquinolines and quinolines with chloroform has been accomplished through in situ electrophilic aryne activation and nucleophile formation. This transition metal-free protocol shows a broad scope of substrates, providing consistently high yields of medicinally-important dihydro(iso)quinoline derivatives. The utility of this method has been further demonstrated in the synthesis of deuterated analogues.

Graphical abstract: Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform

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Publication details

The article was received on 10 Aug 2018, accepted on 19 Sep 2018 and first published on 19 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00838H
Citation: Org. Chem. Front., 2018,5, 3093-3097
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    Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform

    J. Tan, B. Liu and S. Su, Org. Chem. Front., 2018, 5, 3093
    DOI: 10.1039/C8QO00838H

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