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Issue 21, 2018
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Alkylation–peroxidation of α-carbonyl imines or ketones catalyzed by a copper salt via radical-mediated Csp3–H functionalization

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Abstract

The catalytic alkylation–peroxidation of α-carbonyl imines or ketones was enabled by a simple copper salt under very mild reaction conditions. The transformations involved radical-mediated Csp3–H functionalization and afforded stable α-amino or α-alkyloxyl peroxides in good to excellent yields. This strategy would potentially provide a straightforward approach to direct difunctionalization of carbon−heteroatom double bonds and construction of structurally novel organic peroxides.

Graphical abstract: Alkylation–peroxidation of α-carbonyl imines or ketones catalyzed by a copper salt via radical-mediated Csp3–H functionalization

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Publication details

The article was received on 31 Jul 2018, accepted on 17 Sep 2018 and first published on 18 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00797G
Citation: Org. Chem. Front., 2018,5, 3083-3087
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    Alkylation–peroxidation of α-carbonyl imines or ketones catalyzed by a copper salt via radical-mediated Csp3–H functionalization

    M. Lei, Y. Li, S. Cao, X. Hou and L. Gong, Org. Chem. Front., 2018, 5, 3083
    DOI: 10.1039/C8QO00797G

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