Copper-catalyzed direct trifluoromethylthiolation of indoles by tert-butyl 2-((trifluoromethyl)sulfonyl)hydrazine-1-carboxylate

Abstract

In this study, we developed the first copper-catalyzed direct trifluoromethylthiolation of indoles using TfNHNHBoc as a trifluoromethylthiolation reagent. Due to the cheap and readily accessible reagents, as well as its mild reaction conditions and good atom economy, this method is as an alternative and practical strategy for trifluoromethylthiolation of indoles.