3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)–H bond functionalization of 2-alkylazaarenes

T. Beisel; J. Kirchner; T. Kaehler; J. Knauer; Y. Soltani; G. Manolikakes

doi:10.1039/C6OB00108D

This website uses cookies to give you the best user experience. If you continue without changing your settings we'll assume you are happy to receive all RSC cookies. You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions are also obtainable from the privacy link at the bottom of any RSC page.

Lite Version|Standard version

Home > Organic & Biomolecular ... > 3-Component synthesis o...

3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp³)–H bond functionalization of 2-alkylazaarenes

T. Beisel, J. Kirchner, T. Kaehler, J. Knauer, Y. Soltani and G. Manolikakes
Org. Biomol. Chem., 2016,14, 5525-5528
DOI: 10.1039/C6OB00108D, Communication

Open Access Learn more..

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Download

PDF

Rich HTML

Abstract | Cited by

A Brønsted acid-catalyzed addition of 2-alkylazaarenes to in situ generated N-sulfonylimines through selective C(sp³)–H bond functionalization has been developed. This protocol provides an atom- and step-economic approach to α-substituted sulfonamides.

Graphical abstract: 3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)–H bond functionalization of 2-alkylazaarenes

Page: ^ Top

Terms & Conditions | Privacy and Cookies