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Issue 24, 2016
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Direct synthesis of anilines and nitrosobenzenes from phenols

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Abstract

A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution (iSOAr) process. The products are obtained in good yields under mild and metal-free conditions. The leaving group effect on reactions that proceed through mixed quionone monoketals has also been investigated and a predictive model has been established.

Graphical abstract: Direct synthesis of anilines and nitrosobenzenes from phenols

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 12 Jan 2016, accepted on 01 Feb 2016 and first published on 01 Feb 2016


Article type: Communication
DOI: 10.1039/C6OB00073H
Citation: Org. Biomol. Chem., 2016,14, 5520-5524
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    Direct synthesis of anilines and nitrosobenzenes from phenols

    A. H. St. Amant, C. P. Frazier, B. Newmeyer, K. R. Fruehauf and J. Read de Alaniz, Org. Biomol. Chem., 2016, 14, 5520
    DOI: 10.1039/C6OB00073H

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