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Issue 17, 2016
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Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

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Abstract

A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield.

Graphical abstract: Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

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Supplementary files

Article information


Submitted
13 Jun 2016
Accepted
14 Jul 2016
First published
14 Jul 2016

This article is Open Access

Green Chem., 2016,18, 4623-4627
Article type
Communication

Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

M. R. Chapman, M. H. T. Kwan, G. E. King, B. A. Kyffin, A. J. Blacker, C. E. Willans and B. N. Nguyen, Green Chem., 2016, 18, 4623
DOI: 10.1039/C6GC01601D

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