Selective synthesis of trisubstituted (trifluoromethyl)alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl)alkynes†
Abstract
In the presence of catalytic amounts of Cu(OAc)2, the hydroarylation of (trifluoromethyl)alkynes with arylboronic acids proceeded in MeOH at 28 °C to afford diverse β-(trifluoromethyl)styrenes. Moreover, the hydroalkenylation and hydroallylation of a (trifluoromethyl)alkyne using styryl- and allylboronates afforded trifluoromethylated 1,3- and 1,4-dienes.