A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines

Ronald Grigg; Elghareeb E. Elboray; Sunisa Akkarasamiyo; Nutthawat Chuanopparat; H. Ali Dondas; Hussien H. Abbas-Temirek; Colin W. G. Fishwick; Moustafa F. Aly; Boonsong Kongkathip; Ngampong Kongkathip

doi:10.1039/C5CC07526B

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines†

Ronald Grigg,*^a Elghareeb E. Elboray,^ab Sunisa Akkarasamiyo,^ac Nutthawat Chuanopparat,^ac H. Ali Dondas,^d Hussien H. Abbas-Temirek,^b Colin W. G. Fishwick,*^a Moustafa F. Aly,^b Boonsong Kongkathip^c and Ngampong Kongkathip^c

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^a School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK
E-mail: r.grigg@leeds.ac.uk, c.w.g.fishwick@leeds.ac.uk
Fax: +44-0113 343 6565
Tel: +44-0113 343 6510

^b Department of Chemistry, Faculty of Science at Qena, South Valley University, Qena, Egypt

^c Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand

^d Department of Chemistry, Faculty of Pharmacy, Mersin University, Mersin, Turkey

Abstract

Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted functionalised isoquinolinones and isoquinolines in good yields.

Chemical Communications

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines†

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A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines

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