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Issue 1, 2016
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Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

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Abstract

Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

Graphical abstract: Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

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Publication details

The article was received on 05 Aug 2015, accepted on 21 Oct 2015 and first published on 21 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC06565H
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Chem. Commun., 2016,52, 160-163

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    Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

    L. F. Vistain, M. W. Rotz, R. Rathore, A. T. Preslar and T. J. Meade, Chem. Commun., 2016, 52, 160
    DOI: 10.1039/C5CC06565H

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