Fe3O4@SiO2 core–shell nanoparticles for biomedical purposes: adverse effects on blood cells

C. Achilli; S. Grandi; G. F. Guidetti; A. Ciana; C. Tomasi; D. Capsoni; G. Minetti

doi:10.1039/C6BM00374E

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Fe₃O₄@SiO₂ core–shell nanoparticles for biomedical purposes: adverse effects on blood cells†

C. Achilli,‡^a S. Grandi,‡^bc G. F. Guidetti,^a A. Ciana,^a C. Tomasi,^bd D. Capsoni^b and G. Minetti

*^a

Author affiliations

* Corresponding authors

^a University of Pavia, Department of Biology and Biotechnology, Laboratories of Biochemistry, via Bassi 21, Pavia, Italy
E-mail: minetti@unipv.it

^b University of Pavia, Department of Chemistry, viale Taramelli 12, Pavia, Italy

^c Nano Analysis & Materials s.r.l., Via del Carmine 2A, Vigevano, Italy

^d I.E.N.I. C.N.R. Unit of Lecco, corso Promessi Sposi, Lecco, Italy

Abstract

Magnetite nanoparticles coated with silica, obtained by a sol–gel process in the reverse micelle microemulsion, were characterized and homogeneously suspended in water in order to assay their biocompatibility toward blood cells, in view of a potential medical use of this material. Their hemolytic, pro-thrombotic and pro-inflammatory properties were observed.

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Article information

DOI: https://doi.org/10.1039/C6BM00374E
Article type: Communication
Submitted: 02 Jun 2016
Accepted: 02 Aug 2016
First published: 12 Aug 2016

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Biomater. Sci., 2016,4, 1417-1421

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Fe₃O₄@SiO₂ core–shell nanoparticles for biomedical purposes: adverse effects on blood cells

C. Achilli, S. Grandi, G. F. Guidetti, A. Ciana, C. Tomasi, D. Capsoni and G. Minetti, Biomater. Sci., 2016, 4, 1417 DOI: 10.1039/C6BM00374E

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