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Issue 11, 2016
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Migration of phospholipid vesicles in response to OH stimuli

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Abstract

We demonstrate migration of phospholipid vesicles in response to a pH gradient. Upon simple micro-injection of a NaOH solution, the vesicles linearly moved to the tip of the micro-pipette and the migration velocity was proportional to the gradient of OH concentration. Vesicle migration was characteristic of OH ions and no migration was observed for monovalent salts or nonionic sucrose solutions. The migration of vesicles is quantitatively described by the surface tension gradient model where the hydrolysis of the phospholipids by NaOH solution decreases the surface tension of the vesicle. The vesicles move toward a direction where the surface energy decreases. Thus the chemical modification of lipids produces a mechanical force to drive vesicles.

Graphical abstract: Migration of phospholipid vesicles in response to OH− stimuli

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Publication details

The article was received on 03 Sep 2015, accepted on 07 Feb 2016 and first published on 08 Feb 2016


Article type: Paper
DOI: 10.1039/C5SM02220G
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Soft Matter, 2016,12, 2877-2886

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    Migration of phospholipid vesicles in response to OH stimuli

    A. Kodama, Y. Sakuma, M. Imai, Y. Oya, T. Kawakatsu, N. Puff and M. I. Angelova, Soft Matter, 2016, 12, 2877
    DOI: 10.1039/C5SM02220G

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