Issue 93, 2015
From the journal:

RSC Advances

p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents†

Fátima Morales,a   Ana Conejo-García,ab   Alberto Ramírez,c   Cynthia Morata,de   Juan Antonio Marchal*de  and  Joaquín M. Campos*ab  

* Corresponding authors

a Department of Pharmaceutical and Organic Chemistry, c/Campus de Cartuja s/n, Faculty of Pharmacy, University of Granada, 18081 Granada, Spain
E-mail: jmcampos@ugr.es
Fax: +34 958 24 38 45
Tel: +34 958 24 38 50

b Biosanitary Institute of Granada (ibs.GRANADA), SAS-Universidad de Granada, 18071 Granada, Spain

c Department of Health Sciences, Paraje de las Lagunillas s/n, University of Jaén, Jaén, Spain

d Biopathology and Medicine Regenerative Institute (IBIMER), University of Granada, Granada, Spain
E-mail: jmarchal@ugr.es
Fax: +34 958 24 62 96
Tel: +34 958 24 93 21

e Biosanitary Institute of Granada (ibs.GRANADA), 18071 Granada, Spain

Abstract

We have designed and synthesized a novel series of fourteen alkylated purines with notable in vitro anti-proliferative activities against three cancerous cell lines. In vivo studies show absorption by the oral route of administration with systemic distribution and low toxicity for the two more active derivatives.

Graphical abstract: p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents

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Article information

DOI
https://doi.org/10.1039/C5RA13946E
Article type
Communication
Submitted
15 Jul 2015
Accepted
02 Sep 2015
First published
03 Sep 2015
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2015,5, 76615-76619

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p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents

F. Morales, A. Conejo-García, A. Ramírez, C. Morata, J. A. Marchal and J. M. Campos, RSC Adv., 2015, 5, 76615 DOI: 10.1039/C5RA13946E

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