Issue 21, 2015

Facile synthesis of 4- and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C–C and C–N coupling

Abstract

The cyclization of 2,3-dihalopyridines with readily available imines provides a convenient and regioselective approach to 4- and 7-azaindoles. The regioselectivity can be controlled by the choice of the halogen atoms at the pyridine ring (chlorine versus bromine).

Graphical abstract: Facile synthesis of 4- and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C–C and C–N coupling

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2015
Accepted
24 Apr 2015
First published
24 Apr 2015

Org. Biomol. Chem., 2015,13, 6047-6058

Author version available

Facile synthesis of 4- and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C–C and C–N coupling

N. N. Pham, T. T. Dang, N. T. Ngo, A. Villinger, P. Ehlers and P. Langer, Org. Biomol. Chem., 2015, 13, 6047 DOI: 10.1039/C5OB00720H

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